{"id":"W2125700205","doi":"10.1124/jpet.109.164954","title":"Novel Anti-Inflammatory Action of 5-Aminoimidazole-4-carboxamide Ribonucleoside with Protective Effect in Dextran Sulfate Sodium-Induced Acute and Chronic Colitis","year":2010,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Colitis; Inflammation; Inflammatory bowel disease; Proinflammatory cytokine; AMPK; Medicine; Immune system; Immunology; Internal medicine; Pharmacology; Endocrinology; Protein kinase A; Chemistry; Kinase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001092959,0.0003419121,0.0004215649,0.000272288,0.0001555328,0.0001367265,0.0003574016,0.0002718753,0.001266576],"category_scores_gemma":[0.00007428668,0.0001111084,0.0002337584,0.0001500846,0.0001874475,0.0001114922,0.00008919526,0.0004139172,0.0001811481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000122997,"about_ca_system_score_gemma":0.0002014164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005907563,"about_ca_topic_score_gemma":0.001013738,"domain_scores_codex":[0.9999539,0.000009764559,0.000003972073,0.00000838679,0.000008216994,0.00001581036],"domain_scores_gemma":[0.9999654,0.000005575938,0.000008227203,0.000003811579,0.000004430559,0.00001256129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001118193,0.0002572061,0.0001273883,0.000172749,0.0000168293,0.0003000381,0.00001793908,0.0001267732,0.9890688,0.0002100965,0.0001311593,0.008452763],"study_design_scores_gemma":[0.001050244,0.007867763,0.007750396,0.00002773641,0.0001735908,0.001217906,0.00002106815,0.001253416,0.974741,0.00007235457,0.005803967,0.00002052918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883583,0.006017199,0.00219088,0.0001120512,0.00008171599,0.00009100632,0.0001719001,0.0001387558,0.002838135],"genre_scores_gemma":[0.9936329,0.002523441,0.002373793,0.00007570341,0.0000421508,0.00005172449,0.0002711292,0.00001126854,0.001018008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001266576,"threshold_uncertainty_score":0.004237115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.011948229212958,"score_gpt":0.3033298243395842,"score_spread":0.2913815951266261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}