{"id":"W2125711506","doi":"10.1124/dmd.112.048991","title":"NADPH–Cytochrome P450 Oxidoreductase: Roles in Physiology, Pharmacology, and Toxicology","year":2012,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":145,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Center for Complementary and Integrative Health; Cancer Research UK; National Cancer Institute; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institute of General Medical Sciences","keywords":"Cytochrome P450; Cytochrome P450 reductase; Biology; Gene isoform; Microsome; Heme; CYP1A2; Computational biology; Biochemistry; Cell biology; Pharmacology; In vitro; Gene; Metabolism; Cytochrome c; Enzyme; Mitochondrion; Coenzyme Q – cytochrome c reductase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001202323,0.000472339,0.0006702339,0.0003855382,0.0003406065,0.00003359753,0.0002215388,0.0004255934,0.000631688],"category_scores_gemma":[0.00003801319,0.0004549091,0.00009462037,0.0003443805,0.0006256425,0.0005159215,0.0002538193,0.0008236546,0.00006455511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003796764,"about_ca_system_score_gemma":0.00005370718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005963865,"about_ca_topic_score_gemma":0.0000208134,"domain_scores_codex":[0.9966079,0.001014692,0.0005477786,0.0005909538,0.0001614809,0.001077221],"domain_scores_gemma":[0.9986003,0.0002767369,0.0001940557,0.0001915119,0.00006621416,0.0006711697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004853542,0.0007664157,0.003990882,0.00007402101,0.0001323188,0.00001698474,0.002176677,0.00005000649,0.9634187,0.006674373,0.002815438,0.01939881],"study_design_scores_gemma":[0.007277207,0.00006037268,0.5668604,0.00002107779,0.0008926196,0.0002066232,0.0007256055,0.00116288,0.2066118,0.002628921,0.2125466,0.001005883],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.944344,0.05061451,0.00002106628,0.001228714,0.001800149,0.0006160535,0.0002050043,0.00008338327,0.001087088],"genre_scores_gemma":[0.985191,0.008354238,0.0002723332,0.004214995,0.001415202,0.0002052266,0.0001392415,0.00004347776,0.0001642669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.756807,"threshold_uncertainty_score":0.9997903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03321078671532565,"score_gpt":0.373365587240539,"score_spread":0.3401548005252134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}