{"id":"W2125714241","doi":"10.1110/ps.051829106","title":"Protein stabilization by specific binding of guanidinium to a functional arginine‐binding surface on an SH3 domain","year":2005,"lang":"en","type":"article","venue":"Protein Science","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Arginine; Plasma protein binding; Binding domain; Chemistry; SH3 domain; Biophysics; Binding site; Computational biology; Protein structure; Biochemistry; Surface protein; Biology; Amino acid; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008295812,0.0001879534,0.000145359,0.0001165546,0.0002334424,0.00006923151,0.0004330277,0.0001044651,0.00003917348],"category_scores_gemma":[0.000124652,0.0001757501,0.00004293111,0.0006054617,0.0002413439,0.00004018135,0.0001407804,0.0001086612,0.00002127718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008291163,"about_ca_system_score_gemma":0.0001750448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007694439,"about_ca_topic_score_gemma":0.00001276692,"domain_scores_codex":[0.9980576,0.00005590978,0.0002824704,0.0006801871,0.000535643,0.0003881597],"domain_scores_gemma":[0.9990441,0.000006375487,0.0001436522,0.0004643624,0.0001669742,0.000174496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001189502,0.00006152593,0.0002190811,0.000009901117,0.000003366958,3.565339e-7,0.00007699575,0.001174269,0.9946343,0.00189438,0.00009913918,0.001707711],"study_design_scores_gemma":[0.0002861551,0.0005383653,0.0002136496,0.00003584236,0.000001655569,0.000003404677,0.00008717691,0.0003162425,0.9913377,0.0002001499,0.006753504,0.0002261224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712651,0.00007181711,0.02663564,0.0002401746,0.00008413972,0.001027973,0.00004822039,0.00002118246,0.0006057934],"genre_scores_gemma":[0.9724624,0.000003888656,0.02671808,0.00006990205,0.0001515639,0.00006097059,0.00006117149,0.00001943217,0.0004526387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006654365,"threshold_uncertainty_score":0.7166881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01240771443556301,"score_gpt":0.2538189987215313,"score_spread":0.2414112842859683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}