{"id":"W2125714241","doi":"10.1110/ps.051829106","title":"Protein stabilization by specific binding of guanidinium to a functional arginine‐binding surface on an SH3 domain","year":2005,"lang":"en","type":"article","venue":"Protein Science","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Arginine; Plasma protein binding; Binding domain; Chemistry; SH3 domain; Biophysics; Binding site; Computational biology; Protein structure; Biochemistry; Surface protein; Biology; Amino acid; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001826656,0.0002715181,0.0002316396,0.00004683415,0.0001366717,0.0001274571,0.0002249554,0.0002433809,0.0005912379],"category_scores_gemma":[0.0001571723,0.00009043075,0.0001663389,0.00004261608,0.0002714423,0.0001045849,0.0002154975,0.000369863,0.0001294063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001955708,"about_ca_system_score_gemma":0.0001174277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005421491,"about_ca_topic_score_gemma":0.001033154,"domain_scores_codex":[0.9998913,0.00002809316,0.000006199534,0.00002392057,0.0000209605,0.00002955785],"domain_scores_gemma":[0.9999123,0.00002337964,0.00002605145,0.00001014781,0.00001033384,0.00001774754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000028539,0.000006834378,0.00003157834,0.00001063094,0.000001705066,0.00000981351,0.000005364411,0.00003463361,0.9996169,0.00001632189,0.000006924363,0.0002308932],"study_design_scores_gemma":[0.00001044984,0.0001850665,0.0008786108,0.000001971688,0.000005878424,0.00004727018,0.000005554895,0.0005934244,0.9978052,0.00001075303,0.0004536801,0.000002186434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971004,0.0003770913,0.002070311,0.00005999682,0.00001184217,0.00001615738,0.00001992366,0.0000281926,0.0003160535],"genre_scores_gemma":[0.9957975,0.0001950952,0.003297795,0.00004766455,0.000007423332,0.00001613489,0.00006956945,0.00001767102,0.0005510503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005912379,"threshold_uncertainty_score":0.001977921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01240771443556301,"score_gpt":0.2538189987215313,"score_spread":0.2414112842859683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}