{"id":"W2125733229","doi":"10.1172/jci41431","title":"Antiangiogenic cancer therapy combined with oncolytic virotherapy leads to regression of established tumors in mice","year":2010,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"National Cancer Institute; National Institutes of Health; Mayo Foundation for Medical Education and Research","keywords":"Oncolytic virus; Cancer research; Virotherapy; Melanoma; Cancer; Medicine; Viral replication; Immunology; Immune system; Biology; Virus; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001834525,0.0001385962,0.0003988762,0.0001612277,0.00002704789,0.00001853981,0.0003090585,0.0001937798,0.00004295411],"category_scores_gemma":[0.0004283246,0.0000941308,0.0001498858,0.0003292709,0.000220974,0.00001809401,0.00002394334,0.0004309555,0.000001619905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001549147,"about_ca_system_score_gemma":0.0007276571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000365466,"about_ca_topic_score_gemma":0.0008256401,"domain_scores_codex":[0.9980279,0.0002903833,0.0009348973,0.0002075312,0.0003583463,0.0001809644],"domain_scores_gemma":[0.9983993,0.000111496,0.0006323878,0.0002510604,0.000383618,0.0002221786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009763043,0.0001503838,0.1383273,0.000007468877,0.0000479403,0.000004835422,0.00006186741,0.0002231428,0.8437868,0.000004812144,0.0003543329,0.007268054],"study_design_scores_gemma":[0.00383633,0.01137608,0.09252285,0.0001528397,0.00001032586,0.000009222807,0.00002055512,0.00008394818,0.8911701,0.0001425426,0.0005484804,0.000126671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976484,0.0003110412,0.00005054481,0.00148049,0.0002035567,0.0002719155,0.000003447189,0.000002659652,0.00002798543],"genre_scores_gemma":[0.9966325,0.0005936031,0.001463947,0.0008165775,0.0003660056,0.00001006748,0.000006615896,0.00002614508,0.00008457146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04738333,"threshold_uncertainty_score":0.3838543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04772715058878946,"score_gpt":0.3977726898208648,"score_spread":0.3500455392320754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}