{"id":"W2125734502","doi":"10.1016/j.stem.2008.03.021","title":"Global Transcription in Pluripotent Embryonic Stem Cells","year":2008,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":698,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"National Institute on Drug Abuse; National Institutes of Health","keywords":"Biology; Embryonic stem cell; Induced pluripotent stem cell; Chromatin; Gene silencing; Transcription (linguistics); Genome; Genetics; Transcription factor; Cellular differentiation; Cell biology; Gene; Epigenetics; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002974279,0.0003560148,0.0003142436,0.0000991475,0.0001415212,0.0000321354,0.0005332859,0.0003435751,0.00004984613],"category_scores_gemma":[0.000001101103,0.0003666136,0.0002303545,0.0003427459,0.0001236581,0.00001165607,0.0001599336,0.0002170146,0.0003592126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001809992,"about_ca_system_score_gemma":0.0002175475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000659568,"about_ca_topic_score_gemma":0.00007545233,"domain_scores_codex":[0.997221,0.000219642,0.0004416413,0.0008327799,0.0004710308,0.000813891],"domain_scores_gemma":[0.9988557,0.00001338869,0.0001130223,0.0006643794,0.00008897507,0.0002646089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001534476,0.0003694977,0.003176938,0.0001696751,0.00001532527,0.0001499479,0.0001050555,0.001483014,0.9887778,0.000006999989,0.004535219,0.001057107],"study_design_scores_gemma":[0.001946236,0.0003485243,0.001894846,0.00002207514,0.00001452248,0.00005046824,0.000194611,0.0003576478,0.9340274,0.000006546133,0.06067669,0.0004604034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972641,0.004483169,0.0006958786,0.00006150484,0.0004107534,0.0005973743,0.00004808013,0.0000357133,0.02102651],"genre_scores_gemma":[0.9616966,0.001847423,0.0001115184,0.000103087,0.000130302,0.0000429642,0.0000574005,0.00004605455,0.0359646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05614147,"threshold_uncertainty_score":0.9998786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01661325676862228,"score_gpt":0.2299017340087323,"score_spread":0.21328847724011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}