{"id":"W2125747060","doi":"10.1093/toxsci/kfm275","title":"o,p′-DDT Elicits PXR/CAR-, Not ER-, Mediated Responses in the Immature Ovariectomized Rat Liver","year":2007,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Guelph Wellington Seniors Association","funders":"National Institute of General Medical Sciences; U.S. Environmental Protection Agency","keywords":"Constitutive androstane receptor; Pregnane X receptor; Internal medicine; Endocrinology; Oxidative stress; Ovariectomized rat; HMOX1; Estrogen receptor; Nuclear receptor; Chemistry; Biology; Receptor; Pharmacology; Estrogen; Medicine; Biochemistry; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001005781,0.0003301855,0.000248874,0.0002964609,0.0001134924,0.0001764538,0.0001021841,0.0001690219,0.001484201],"category_scores_gemma":[0.00008205067,0.0001995068,0.0002663016,0.0002186903,0.000228837,0.0001423851,0.0001247754,0.0004328037,0.0003460102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002363505,"about_ca_system_score_gemma":0.0002421977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00133224,"about_ca_topic_score_gemma":0.00310261,"domain_scores_codex":[0.9999013,0.000009024257,0.000007453213,0.00003219369,0.00002089883,0.00002907068],"domain_scores_gemma":[0.9999005,0.0000143496,0.0000292644,0.0000120557,0.00001432371,0.00002944176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001821954,0.00002322802,0.0001820415,0.00001428329,0.000002435074,0.00002463562,0.00001143209,0.00001598704,0.9991685,0.00001412937,0.00001697066,0.0003441766],"study_design_scores_gemma":[0.00002111366,0.001046333,0.01375548,0.000004356133,0.00001874052,0.0001518845,0.00007569059,0.0002662388,0.9837312,0.00003383104,0.0008897912,0.000005297706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968432,0.0006103783,0.0008071068,0.00006269533,0.00002193785,0.00001770305,0.0006875049,0.00004848302,0.0009010279],"genre_scores_gemma":[0.9906487,0.0009460541,0.00141644,0.00009272034,0.00001749186,0.00006349129,0.001466829,0.00001954046,0.005328751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001484201,"threshold_uncertainty_score":0.004965186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02242533951658317,"score_gpt":0.2961724147785161,"score_spread":0.2737470752619329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}