{"id":"W2125747060","doi":"10.1093/toxsci/kfm275","title":"o,p′-DDT Elicits PXR/CAR-, Not ER-, Mediated Responses in the Immature Ovariectomized Rat Liver","year":2007,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Guelph Wellington Seniors Association","funders":"National Institute of General Medical Sciences; U.S. Environmental Protection Agency","keywords":"Constitutive androstane receptor; Pregnane X receptor; Internal medicine; Endocrinology; Oxidative stress; Ovariectomized rat; HMOX1; Estrogen receptor; Nuclear receptor; Chemistry; Biology; Receptor; Pharmacology; Estrogen; Medicine; Biochemistry; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002817746,0.0001664953,0.0001744065,0.0000650678,0.0002472356,0.00005549708,0.0005668121,0.0004177697,0.00006238114],"category_scores_gemma":[0.00101256,0.00008523862,0.00009481827,0.0005304536,0.0005742831,0.000007381356,0.0001186245,0.0003048033,0.00003749337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001519496,"about_ca_system_score_gemma":0.00007556786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001894336,"about_ca_topic_score_gemma":0.00006203738,"domain_scores_codex":[0.9981412,0.0004194129,0.0002300411,0.0004070262,0.0003193825,0.0004829967],"domain_scores_gemma":[0.999084,0.0005298229,0.00007622899,0.0001827417,0.00003275022,0.00009445343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001378511,0.0001464881,0.001274997,0.000003085666,0.0000120097,0.0001173052,0.0001222884,0.0000261582,0.9941743,0.0003968494,0.001163008,0.001184988],"study_design_scores_gemma":[0.002381942,0.003221668,0.1571393,0.00002360483,0.00003168911,0.000161794,0.0004702231,0.0002805386,0.8127564,0.0002690197,0.02270968,0.0005541141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942324,0.001558567,0.00005823996,0.0008926965,0.0001792579,0.0003128829,0.000003636589,0.00002360376,0.002738722],"genre_scores_gemma":[0.9968146,0.0002925988,0.0003180392,0.002142267,0.0001349421,0.0000164602,0.00001186364,0.00000500085,0.0002641926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1814179,"threshold_uncertainty_score":0.347593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02242533951658317,"score_gpt":0.2961724147785161,"score_spread":0.2737470752619329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}