{"id":"W2125747195","doi":"10.1152/ajpheart.00703.2010","title":"Endogenous HMGB1 contributes to ischemia-reperfusion-induced myocardial apoptosis by potentiating the effect of TNF-α/JNK","year":2010,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"U.S. Public Health Service","keywords":"HMGB1; Myocyte; Apoptosis; Tumor necrosis factor alpha; Phosphorylation; Cardiac myocyte; Chemistry; Kinase; Internal medicine; Cell biology; Inflammation; Endocrinology; Biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003409554,0.0005050034,0.0004738735,0.0002489551,0.0001722761,0.0002556854,0.0001917375,0.000281533,0.001083227],"category_scores_gemma":[0.0001508458,0.0001873101,0.0004848426,0.0001396907,0.0002635678,0.0002851558,0.0002644977,0.0006903296,0.0003066457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000202209,"about_ca_system_score_gemma":0.000237752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002976356,"about_ca_topic_score_gemma":0.0003716435,"domain_scores_codex":[0.9998429,0.00004019872,0.00002098048,0.00001945357,0.0000314899,0.00004502228],"domain_scores_gemma":[0.9998803,0.00001176599,0.00003793127,0.00001209002,0.00001641294,0.00004143003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001335,0.0001419827,0.0006076177,0.0002889412,0.00002887675,0.0002073805,0.00004694339,0.00005028175,0.9946015,0.0001339133,0.00006127841,0.002496223],"study_design_scores_gemma":[0.0001682045,0.001882787,0.01513674,0.0000617842,0.0001072577,0.0008070341,0.0001223047,0.001157866,0.9774083,0.0001851695,0.002952781,0.000009644749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779071,0.01750475,0.00284698,0.0002383253,0.0001061316,0.00005370694,0.0001132122,0.00004833452,0.001181492],"genre_scores_gemma":[0.9905961,0.006070885,0.001550222,0.0001087978,0.00005580041,0.00006442329,0.0002105496,0.00000766114,0.001335627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001083227,"threshold_uncertainty_score":0.003623724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006999217721156413,"score_gpt":0.256094966788201,"score_spread":0.2490957490670446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}