{"id":"W2125755807","doi":"10.1158/1535-7163.mct-14-0399","title":"ANG4043, a Novel Brain-Penetrant Peptide–mAb Conjugate, Is Efficacious against HER2-Positive Intracranial Tumors in Mice","year":2014,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Angiochem (Canada)","funders":"","keywords":"Transcytosis; Monoclonal antibody; Cancer research; Conjugate; LRP1; In vivo; Blood–brain barrier; In vitro; Biology; Antibody; Receptor; Pharmacology; Immunology; Central nervous system; Biochemistry; Endocrinology; Endocytosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000117519,0.0005505261,0.0002926195,0.000332747,0.0001151011,0.0002483728,0.0002397582,0.0003817049,0.0006126629],"category_scores_gemma":[0.00006606689,0.000182283,0.0001996255,0.0001872937,0.0001882885,0.0002283616,0.00009184234,0.0005435772,0.0002543326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003178819,"about_ca_system_score_gemma":0.0002422747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000715851,"about_ca_topic_score_gemma":0.0009386797,"domain_scores_codex":[0.9998926,0.00001866982,0.000005331007,0.00001905302,0.00003580228,0.00002850416],"domain_scores_gemma":[0.99993,0.000008659314,0.00002689463,0.000005146081,0.000006973379,0.00002215859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001510089,0.00006899964,0.00007412796,0.00002248723,0.000006567758,0.00004392338,0.000006458391,0.00009863186,0.9977387,0.00006780647,0.00006197824,0.001659266],"study_design_scores_gemma":[0.00008771967,0.002798917,0.003328222,0.000004212387,0.00003814785,0.0005715913,0.000009230405,0.001177272,0.9884973,0.00007117604,0.003408185,0.000008092054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993021,0.00141079,0.002796109,0.0001039228,0.00003562592,0.00005271108,0.0002151622,0.0002153174,0.002149374],"genre_scores_gemma":[0.9926355,0.00139629,0.002837173,0.00006542499,0.00002868074,0.00004526333,0.000461003,0.00002692945,0.002503782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000715851,"threshold_uncertainty_score":0.002306461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0195238399491707,"score_gpt":0.3064393769036586,"score_spread":0.2869155369544879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}