{"id":"W2125802188","doi":"10.1161/circresaha.111.256560","title":"Abnormal Termination of Ca <sup>2+</sup> Release Is a Common Defect of RyR2 Mutations Associated With Cardiomyopathies","year":2012,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Ryanodine receptor 2; Ryanodine receptor; Cardiomyopathy; Chemistry; Internal medicine; Endoplasmic reticulum; Heart failure; Biology; Endocrinology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009886848,0.00009125807,0.000322866,0.0003546452,0.0001423811,0.000006016908,0.00004520397,0.0001295787,0.00007212039],"category_scores_gemma":[0.0005552439,0.00008025184,0.0001536434,0.0007158419,0.00027824,0.0001706191,0.00002594515,0.0003179166,0.0000164525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001084133,"about_ca_system_score_gemma":0.0001761212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001531805,"about_ca_topic_score_gemma":0.000005351321,"domain_scores_codex":[0.9982896,0.0004187521,0.0002608386,0.0001473131,0.0005649518,0.0003184798],"domain_scores_gemma":[0.9983755,0.0004184772,0.0001104007,0.0002626816,0.0007332448,0.00009964497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009137525,0.0006986279,0.9297284,0.0005040398,0.0008743491,0.00007717478,0.01116181,0.02509061,0.02225315,0.0008656888,0.00128021,0.006552133],"study_design_scores_gemma":[0.001107631,0.0003821628,0.9792014,0.0001586234,0.000165996,0.00008468567,0.0005533664,0.01120234,0.006842003,0.0001616735,0.00004174442,0.00009834249],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971572,0.0002515558,0.00007845318,0.000215993,0.00001731271,0.0004217697,0.00003095158,0.0000197096,0.001807051],"genre_scores_gemma":[0.9994364,0.00001394796,0.00003605511,0.00003280182,0.00009939694,0.00003911602,0.000206386,0.00001557851,0.0001203401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04947298,"threshold_uncertainty_score":0.3272575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03536481073229456,"score_gpt":0.3408920106971553,"score_spread":0.3055271999648607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}