{"id":"W2125802963","doi":"10.1016/j.neurobiolaging.2015.09.009","title":"A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin","year":2015,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Janssen Research and Development; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Servier; Eisai; Pfizer; BioClinica; Wellcome Trust; Wellcome; Synarc; F. Hoffmann-La Roche; Bristol-Myers Squibb; U.S. Public Health Service; U.S. Department of Defense; Eli Lilly and Company; BrightFocus Foundation; Novartis Pharmaceuticals Corporation; Takeda Pharmaceutical Company; Medpace; Genentech; Biogen Idec; Merck; Alzheimer's Drug Discovery Foundation; American Federation for Aging Research; Fujirebio Europe; Alzheimer's Association; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Medical Research Council; Johnson and Johnson; Meso Scale Diagnostics","keywords":"Clusterin; Apolipoprotein E; Cerebrospinal fluid; Neurodegeneration; Endophenotype; Pathogenesis; Alzheimer's disease; Genome-wide association study; Amyloid beta; Immunology; Disease; Biology; Medicine; Internal medicine; Gene; Genetics; Neuroscience; Genotype; Single-nucleotide polymorphism; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003061614,0.0007008374,0.0004402987,0.001384306,0.0007448554,0.0007191539,0.0005741718,0.0006446218,0.001626006],"category_scores_gemma":[0.001822997,0.0001295985,0.0002268451,0.0009911781,0.0006478942,0.0004456759,0.0006293107,0.0004462145,0.0001215091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004053523,"about_ca_system_score_gemma":0.0004222969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004268597,"about_ca_topic_score_gemma":0.003626088,"domain_scores_codex":[0.9997419,0.00004683506,0.00002556398,0.00006629527,0.00006536275,0.00005402632],"domain_scores_gemma":[0.9992861,0.0001853801,0.0002491625,0.00004664178,0.000119808,0.0001128594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002252087,0.0001178937,0.8936626,0.00009459683,0.0002329619,0.009779019,0.0006450166,0.0002273358,0.07669289,0.001579623,0.001396334,0.01331962],"study_design_scores_gemma":[0.00002887019,0.0002438167,0.9739771,0.00004088887,0.0001365407,0.01297677,0.00073898,0.0006057682,0.007792589,0.001918849,0.001512131,0.0000275346],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979316,0.0002914463,0.0003515978,0.0002407898,0.00001838605,0.000009161188,0.0002495296,0.00000920302,0.000898256],"genre_scores_gemma":[0.9985902,0.0001648448,0.0006230786,0.00007374392,0.00002090601,0.000008798052,0.0001795072,0.000008286228,0.0003305244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004268597,"threshold_uncertainty_score":0.008487463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0471589381135304,"score_gpt":0.3161424004224592,"score_spread":0.2689834623089288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}