{"id":"W2125802963","doi":"10.1016/j.neurobiolaging.2015.09.009","title":"A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin","year":2015,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Janssen Research and Development; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Servier; Eisai; Pfizer; BioClinica; Wellcome Trust; Wellcome; Synarc; F. Hoffmann-La Roche; Bristol-Myers Squibb; U.S. Public Health Service; U.S. Department of Defense; Eli Lilly and Company; BrightFocus Foundation; Novartis Pharmaceuticals Corporation; Takeda Pharmaceutical Company; Medpace; Genentech; Biogen Idec; Merck; Alzheimer's Drug Discovery Foundation; American Federation for Aging Research; Fujirebio Europe; Alzheimer's Association; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Medical Research Council; Johnson and Johnson; Meso Scale Diagnostics","keywords":"Clusterin; Apolipoprotein E; Cerebrospinal fluid; Neurodegeneration; Endophenotype; Pathogenesis; Alzheimer's disease; Genome-wide association study; Amyloid beta; Immunology; Disease; Biology; Medicine; Internal medicine; Gene; Genetics; Neuroscience; Genotype; Single-nucleotide polymorphism; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001575974,0.0001731598,0.0003756002,0.0001176573,0.00004637582,0.000005218352,0.0001512134,0.00008604059,0.0000555872],"category_scores_gemma":[0.0001645934,0.0001651553,0.0001521624,0.00008016285,0.0002503612,0.00004012463,0.0001761701,0.0001203691,0.00002411445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002399535,"about_ca_system_score_gemma":0.0001782384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009081653,"about_ca_topic_score_gemma":0.000001198061,"domain_scores_codex":[0.9987722,0.0000890755,0.000314414,0.0003818538,0.00009738385,0.0003450876],"domain_scores_gemma":[0.9989707,0.00007007594,0.0001162826,0.0003759426,0.0001665183,0.0003004971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.04705827,0.00302266,0.4033292,0.002554059,0.001862818,0.00205967,0.001867328,0.00424254,0.466462,0.002910584,0.04884936,0.01578152],"study_design_scores_gemma":[0.02828141,0.00844356,0.8944293,0.0004259496,0.004127433,0.002353989,0.0003547065,0.007250304,0.0334098,0.003135546,0.01646342,0.001324616],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993104,0.001017226,0.001251861,0.002158652,0.001192487,0.000661578,0.00007947304,0.00009932721,0.0004353852],"genre_scores_gemma":[0.9960542,0.00001057888,0.002330995,0.0009718764,0.0003419557,0.00005051044,0.0000952877,0.00003514719,0.0001094193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4911001,"threshold_uncertainty_score":0.6734837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0471589381135304,"score_gpt":0.3161424004224592,"score_spread":0.2689834623089288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}