{"id":"W2125825231","doi":"10.1128/aac.00256-11","title":"The <i>pmrCAB</i> Operon Mediates Polymyxin Resistance in <i>Acinetobacter baumannii</i> ATCC 17978 and Clinical Isolates through Phosphoethanolamine Modification of Lipid A","year":2011,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":273,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Universidad de Sevilla","keywords":"Acinetobacter baumannii; Polymyxin; Microbiology; Operon; Lipid A; Acinetobacter; Polymyxin B; Biology; Bacteria; Drug resistance; Antibiotics; Pseudomonas aeruginosa; Gene; Genetics; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001266639,0.0004524299,0.0002678677,0.0002138725,0.0001340859,0.0003167783,0.0002525671,0.0002110074,0.000636133],"category_scores_gemma":[0.0002469158,0.0001480177,0.0002979181,0.0002113712,0.0001786509,0.0001473799,0.0002525501,0.0004138754,0.0003710286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003677233,"about_ca_system_score_gemma":0.0003208361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002306829,"about_ca_topic_score_gemma":0.00142537,"domain_scores_codex":[0.9997248,0.00004029434,0.00003007305,0.00005628135,0.00009085536,0.00005774342],"domain_scores_gemma":[0.9998292,0.00001726238,0.0000745182,0.00002054961,0.00002482432,0.00003372758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004122223,0.00001917379,0.0008682284,0.00001370199,0.000003310065,0.00003654446,0.00001198348,0.00004132512,0.9985009,0.00002512905,0.00002564606,0.0004128215],"study_design_scores_gemma":[0.00001627022,0.0002049038,0.02836962,0.000009865403,0.00003070019,0.0007905679,0.0001011796,0.001309652,0.9676183,0.00004577902,0.001492703,0.00001050139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976109,0.000206132,0.001143079,0.00009716624,0.00000968848,0.00002217261,0.00041287,0.00005286223,0.0004451353],"genre_scores_gemma":[0.9950166,0.0001838586,0.002736351,0.0000485269,0.000008422272,0.00003922281,0.00124406,0.00002791834,0.000695105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002306829,"threshold_uncertainty_score":0.004586756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02191931336177355,"score_gpt":0.2754867470809508,"score_spread":0.2535674337191773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}