{"id":"W2125829114","doi":"10.1186/1478-811x-12-19","title":"Prostaglandin E2 alters Wnt-dependent migration and proliferation in neuroectodermal stem cells: implications for autism spectrum disorders","year":2014,"lang":"en","type":"article","venue":"Cell Communication and Signaling","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Wnt signaling pathway; Biology; LRP6; LRP5; Prostaglandin E2; Cell biology; Downregulation and upregulation; Stem cell; WNT3A; Enhancer; Neuroscience; Signal transduction; Endocrinology; Genetics; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000309307,0.0001191413,0.0001008415,0.00005598965,0.0002043521,0.0000899357,0.0001232214,0.00008071513,0.000001898355],"category_scores_gemma":[0.000008009806,0.0001229637,0.00002502116,0.00005291949,0.00004077149,0.00001584839,0.00006374442,0.0000798208,4.258579e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001504524,"about_ca_system_score_gemma":0.00002874726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000156509,"about_ca_topic_score_gemma":0.0002192295,"domain_scores_codex":[0.9992412,0.0001077496,0.0001912888,0.0002537944,0.00005388298,0.0001520802],"domain_scores_gemma":[0.9995681,0.00004484949,0.00009949674,0.0002210059,0.00002018081,0.00004639063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009190467,0.0000692356,0.03428435,0.00008711811,0.00001591737,4.708587e-8,0.0007546865,0.0006989237,0.9576738,0.001968329,0.0002140628,0.004141661],"study_design_scores_gemma":[0.002814251,0.0003545647,0.01513828,0.00006629151,0.00004248694,0.00000534714,0.0003594848,0.0128039,0.9519727,0.005011519,0.01082275,0.0006084674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777088,0.001040258,0.0162148,0.004307353,0.00004470131,0.0005419671,0.000006085232,0.00001669489,0.0001193819],"genre_scores_gemma":[0.9972082,0.001026673,0.0009296102,0.0001750434,0.00002964969,0.0001719689,0.0001649552,0.00001713093,0.0002767996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01949941,"threshold_uncertainty_score":0.5014315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01158102583291031,"score_gpt":0.2328111211665231,"score_spread":0.2212300953336128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}