{"id":"W2125836344","doi":"10.1038/nchembio.1060","title":"Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis","year":2012,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":825,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Argonne National Laboratory; Biological and Environmental Research; National Institute of General Medical Sciences; National Institute of Mental Health; National Cancer Institute; National Institutes of Health; Knut och Alice Wallenbergs Stiftelse; Wellcome Trust; Canadian Institutes of Health Research; Genome Canada; University of Chicago; Howard Hughes Medical Institute","keywords":"PKM2; Pyruvate kinase; Biochemistry; Glycolysis; Cell growth; Tyrosine kinase; Kinase; Biology; Pyruvate dehydrogenase kinase; Chemistry; Cell biology; Enzyme; Pyruvate dehydrogenase complex; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005612436775688443,"score_gpt":0.2536012332319925,"score_spread":0.2479887964563041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}