{"id":"W2125847937","doi":"10.1039/c5sc00038f","title":"Regioselective thioacetylation of chitosan end-groups for nanoparticle gene delivery systems","year":2015,"lang":"en","type":"article","venue":"Chemical Science","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada); Polytechnique Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Université de Montréal; Polytechnique Montréal","keywords":"Chitosan; Oxime; Regioselectivity; Combinatorial chemistry; Gene delivery; Chemistry; Aqueous solution; Nanoparticle; Polymer; Click chemistry; Nanotechnology; Organic chemistry; Materials science; Gene; Biochemistry; Genetic enhancement; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002499424,0.0003918763,0.0001600932,0.000184615,0.0001395717,0.0002267115,0.0003116341,0.000295035,0.0009981989],"category_scores_gemma":[0.0003036463,0.0002367686,0.0002308241,0.0001639392,0.000258778,0.0002657464,0.0001832268,0.0004105103,0.0004283119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004191514,"about_ca_system_score_gemma":0.0003616499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009059742,"about_ca_topic_score_gemma":0.00221751,"domain_scores_codex":[0.999832,0.00002884402,0.00001790942,0.00003400624,0.00005488855,0.00003220918],"domain_scores_gemma":[0.9998605,0.00002973483,0.00004061023,0.00002050138,0.00002903675,0.00001948756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002778382,0.000006764118,0.00002919549,0.00002822229,0.000003647465,0.00003028586,0.00001660139,0.00008356201,0.9985911,0.0001669502,0.00003940653,0.0009763745],"study_design_scores_gemma":[0.000003983849,0.00004072853,0.0001364416,7.517553e-7,0.000004172777,0.00004711503,0.000002545728,0.0002567214,0.9989876,0.00001209549,0.0005044474,0.000003431605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701264,0.001055554,0.02300799,0.0002442663,0.00005324031,0.0001390037,0.0002506917,0.0003562276,0.004766661],"genre_scores_gemma":[0.9884697,0.0005599222,0.007407769,0.00007208585,0.00001323417,0.00004312311,0.0001702432,0.00005786166,0.003206138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009981989,"threshold_uncertainty_score":0.003339291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02507961420872578,"score_gpt":0.2635934438702427,"score_spread":0.2385138296615169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}