{"id":"W2125850880","doi":"10.1016/j.bmc.2015.11.005","title":"Design, synthesis and evaluation of antiestrogen and histone deacetylase inhibitor molecular hybrids","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; McGill University","funders":"Canadian Institutes of Health Research; Fondation du cancer du sein du Québec","keywords":"Chemistry; Histone deacetylase inhibitor; Antiestrogen; Histone deacetylase; HDAC6; Stereochemistry; Biochemistry; Pharmacology; Histone; Genetics; Tamoxifen; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001920121,0.0002540554,0.0001883512,0.000236774,0.0001724505,0.0003267612,0.0004315091,0.0003052776,0.00205354],"category_scores_gemma":[0.0001473177,0.0001669851,0.0002276143,0.0001794451,0.0001074832,0.0002757496,0.0001882652,0.0003429608,0.0004470467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003882074,"about_ca_system_score_gemma":0.0001929867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003813155,"about_ca_topic_score_gemma":0.0008629396,"domain_scores_codex":[0.9999263,0.00001086687,0.000004933637,0.00001625005,0.00001920691,0.00002252611],"domain_scores_gemma":[0.9999509,0.000009014055,0.00001333027,0.000004522064,0.00001111024,0.00001115919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003236214,0.0002379494,0.0003041067,0.0002378816,0.00005995027,0.0002248408,0.00007787146,0.00408791,0.9677999,0.00367232,0.0005331861,0.02244043],"study_design_scores_gemma":[0.00008295906,0.001764221,0.0006712091,0.00001138631,0.00007197463,0.0001924072,0.00003907774,0.002094578,0.9746652,0.000246775,0.02013824,0.00002208691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9510527,0.006877287,0.02746993,0.0004187443,0.0001396969,0.0003427049,0.0008537811,0.0003121249,0.01253308],"genre_scores_gemma":[0.9756932,0.002681779,0.01304579,0.0001490394,0.00001847334,0.0001533716,0.0005465858,0.00002259765,0.007689097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00205354,"threshold_uncertainty_score":0.006869733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03669522753424448,"score_gpt":0.3114211009657903,"score_spread":0.2747258734315458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}