{"id":"W2125850880","doi":"10.1016/j.bmc.2015.11.005","title":"Design, synthesis and evaluation of antiestrogen and histone deacetylase inhibitor molecular hybrids","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; McGill University","funders":"Canadian Institutes of Health Research; Fondation du cancer du sein du Québec","keywords":"Chemistry; Histone deacetylase inhibitor; Antiestrogen; Histone deacetylase; HDAC6; Stereochemistry; Biochemistry; Pharmacology; Histone; Genetics; Tamoxifen; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001517996,0.0002256514,0.0002749731,0.00004777037,0.00005355179,0.000013347,0.0001578504,0.0002134377,0.00003674964],"category_scores_gemma":[0.001466711,0.0002242193,0.00004199527,0.0001316387,0.0004541871,0.000007260497,0.0001618782,0.0001447914,0.000003507553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001104904,"about_ca_system_score_gemma":0.0006507908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003348636,"about_ca_topic_score_gemma":0.000001430791,"domain_scores_codex":[0.9979835,0.000171703,0.0003190579,0.000478707,0.0007719386,0.0002751478],"domain_scores_gemma":[0.9986491,0.00003863411,0.0001310373,0.0003914447,0.0004380182,0.0003517831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001336037,0.00005795515,0.0001445803,0.00009488865,0.00005540857,0.00001509676,0.00008677526,0.000004892916,0.9951657,0.000001521268,0.001869437,0.002370125],"study_design_scores_gemma":[0.001165458,0.0001837489,0.00008558674,0.00006650783,0.0001484313,0.0002212905,0.0002973813,0.0002301927,0.996761,0.00002357384,0.0006100647,0.0002067154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871385,0.01143921,0.000532776,0.0001848263,0.00005938128,0.0002495606,0.00001543131,0.00001398858,0.0003663853],"genre_scores_gemma":[0.9987265,0.0001570599,0.0006445342,0.00003225761,0.0002086099,0.00003412917,0.00003887176,0.00003715276,0.000120877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01158807,"threshold_uncertainty_score":0.9143398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03669522753424448,"score_gpt":0.3114211009657903,"score_spread":0.2747258734315458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}