{"id":"W2125851399","doi":"10.1016/j.ebiom.2015.03.017","title":"Mitochondrial Manipulation and the Quest for Alzheimer's Treatments","year":2015,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; AGE-WELL","keywords":"Mitochondrion; Chemistry; Respiratory chain; Alzheimer's disease; Oxidative stress; Mitochondrial respiratory chain; Biology; Biochemistry; Cell biology; Neuroscience; Biophysics; Disease; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000214944,0.0001537554,0.0002950944,0.00009180456,0.0001021297,0.00001718568,0.00005154906,0.00005571363,0.00002711822],"category_scores_gemma":[0.0001424231,0.00008092535,0.00007056904,0.0001312586,0.0003153987,0.00006749913,0.00002823071,0.00006481418,0.00004040312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005774403,"about_ca_system_score_gemma":0.0001316518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001620139,"about_ca_topic_score_gemma":0.000007941469,"domain_scores_codex":[0.9988822,0.00004976818,0.0001941593,0.0002420556,0.0003747509,0.0002570749],"domain_scores_gemma":[0.9989694,0.0001315832,0.00005597263,0.0002487044,0.0001447403,0.000449584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1468603,0.007316643,0.1413182,0.0005382634,0.1703256,0.001543439,0.008609569,0.000008617681,0.001614405,0.02537171,0.3116658,0.1848275],"study_design_scores_gemma":[0.6264258,0.01923138,0.1706238,0.0008173459,0.04181841,0.001210231,0.002639524,0.009105249,0.003138435,0.02736947,0.09638634,0.001234026],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6785729,0.1947231,0.002204239,0.07895616,0.003453454,0.02096666,0.0002921739,0.0005438034,0.02028745],"genre_scores_gemma":[0.9965088,0.0001329135,0.0009314189,0.0003858912,0.001001316,0.0002638637,0.0003998007,0.00002576412,0.000350175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4795655,"threshold_uncertainty_score":0.330004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08000673745911495,"score_gpt":0.3615040817105235,"score_spread":0.2814973442514085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}