{"id":"W2125948889","doi":"10.1093/hmg/ddn257","title":"Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia","year":2008,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":295,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; U.S. Public Health Service; National Institute on Aging; National Institutes of Health; Canadian Institutes of Health Research; Mayo Foundation for Medical Education and Research","keywords":"Frontotemporal dementia; Biology; Frontotemporal lobar degeneration; Allele; Genetics; Dementia; microRNA; Mutation; Cancer research; Disease; Pathology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002389321,0.000160653,0.0002769677,0.0001278579,0.0001573183,0.00001815896,0.0001791128,0.000121999,0.0001270418],"category_scores_gemma":[0.00003495942,0.0001259771,0.0001424765,0.0001716799,0.0001113946,0.00003023485,0.0000653859,0.000219652,0.00001614054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007652171,"about_ca_system_score_gemma":0.00005586703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005799065,"about_ca_topic_score_gemma":0.000142934,"domain_scores_codex":[0.9983482,0.0001951939,0.0003715312,0.0002656616,0.0005046033,0.0003148576],"domain_scores_gemma":[0.9991655,0.00004864784,0.0001664832,0.0004022201,0.0001401169,0.00007702064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002593252,0.0004194374,0.2749696,0.0000919729,0.0003748777,0.00009272675,0.009858982,0.00003707188,0.7121555,0.00008982569,0.0007883554,0.000862364],"study_design_scores_gemma":[0.002087611,0.0007016342,0.9828432,0.00004749603,0.0001494625,0.000009493124,0.0000318802,0.000807908,0.01276222,0.0002303563,0.0002032834,0.0001255031],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994198,0.0005764966,0.003398627,0.0002403595,0.00002729945,0.001184372,0.0002407714,0.00001102501,0.0001230839],"genre_scores_gemma":[0.9965576,0.0001025289,0.002773887,0.0002567181,0.00004938909,0.00004857477,0.0001002494,0.00003335264,0.00007768418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7078735,"threshold_uncertainty_score":0.5137195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03862974560396363,"score_gpt":0.3119650823734754,"score_spread":0.2733353367695117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}