{"id":"W2125955712","doi":"10.1016/j.biopsych.2014.06.016","title":"DNA Modification Study of Major Depressive Disorder: Beyond Locus-by-Locus Comparisons","year":2014,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Public Health Ontario; Centre for Addiction and Mental Health","funders":"National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Canadian Institutes of Health Research; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw","keywords":"Epigenetics; Major depressive disorder; DNA methylation; Prefrontal cortex; Biology; Epigenomics; Locus (genetics); Genetics; DNA microarray; CpG site; Computational biology; Bioinformatics; Neuroscience; Gene; Gene expression; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002052772,0.0001756747,0.0002244793,0.00003201962,0.0001077142,0.00001354587,0.0002507663,0.0002399064,0.0000179529],"category_scores_gemma":[0.00008349992,0.0001372028,0.00008541493,0.00009446779,0.00009109805,0.000002502718,0.00008967415,0.0000949889,0.000008846097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004986681,"about_ca_system_score_gemma":0.00001960598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004355758,"about_ca_topic_score_gemma":0.00008169377,"domain_scores_codex":[0.9986606,0.0002035532,0.0003608143,0.0004497129,0.0001255567,0.0001997181],"domain_scores_gemma":[0.9991598,0.00002735784,0.0002150617,0.000437778,0.00007788634,0.00008214134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000150478,0.001726069,0.4795724,0.00001446965,0.00007380643,9.941787e-8,0.00003515909,0.0001900162,0.5105715,0.0006475524,0.002627662,0.004390802],"study_design_scores_gemma":[0.01037628,0.01425254,0.6487049,0.00003486952,0.0002438119,0.00000313226,0.001480766,0.0008561331,0.2399914,0.01076901,0.0715223,0.001764899],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806169,0.003267461,0.01424876,0.0002067132,0.0002789682,0.0003491299,0.00003026702,0.00001677284,0.0009850417],"genre_scores_gemma":[0.9985554,0.000142199,0.0006921372,0.00007590394,0.0001855272,0.00003788047,0.0002308348,0.00001381143,0.00006633847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2705802,"threshold_uncertainty_score":0.5594968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01682626903969615,"score_gpt":0.2805604831706922,"score_spread":0.263734214130996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}