{"id":"W2125955712","doi":"10.1016/j.biopsych.2014.06.016","title":"DNA Modification Study of Major Depressive Disorder: Beyond Locus-by-Locus Comparisons","year":2014,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Public Health Ontario; Centre for Addiction and Mental Health","funders":"National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Canadian Institutes of Health Research; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw","keywords":"Epigenetics; Major depressive disorder; DNA methylation; Prefrontal cortex; Biology; Epigenomics; Locus (genetics); Genetics; DNA microarray; CpG site; Computational biology; Bioinformatics; Neuroscience; Gene; Gene expression; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006683609,0.0002061972,0.0002828608,0.0005605299,0.0001710668,0.0002620844,0.0002390191,0.0002586719,0.0007760415],"category_scores_gemma":[0.001136364,0.0001134684,0.0001868449,0.0004921061,0.0002273601,0.0001476208,0.0003588279,0.0003192392,0.0001158336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000201293,"about_ca_system_score_gemma":0.0001546707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007238359,"about_ca_topic_score_gemma":0.00151564,"domain_scores_codex":[0.9996643,0.0001223306,0.00001881917,0.0001248228,0.0000477524,0.00002193808],"domain_scores_gemma":[0.9995371,0.000174404,0.0001233907,0.00007200122,0.00004799253,0.00004507849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008789038,0.0001143304,0.293033,0.0002342913,0.0007384346,0.0001783141,0.0002962129,0.001010741,0.6612986,0.000992827,0.0001619875,0.04106238],"study_design_scores_gemma":[0.00003409381,0.0005767856,0.9183103,0.00001658251,0.0002749764,0.000676848,0.0001096689,0.005509488,0.0704022,0.002607014,0.001458936,0.00002304607],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864955,0.0008938063,0.01137455,0.00008934044,0.00001051321,0.00003130395,0.0004662499,0.00003118673,0.000607524],"genre_scores_gemma":[0.9926872,0.0001783413,0.006632414,0.00005828103,0.000006749421,0.00001687113,0.0002049809,0.000007393204,0.0002076726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007760415,"threshold_uncertainty_score":0.003534675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01682626903969615,"score_gpt":0.2805604831706922,"score_spread":0.263734214130996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}