{"id":"W2126007462","doi":"10.1074/jbc.m314276200","title":"Aromatic Residue Position on the Nonpolar Face of Class A Amphipathic Helical Peptides Determines Biological Activity","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; McMaster University Medical Centre","funders":"National Heart, Lung, and Blood Institute","keywords":"Residue (chemistry); Amphiphile; Chemistry; Position (finance); Stereochemistry; Crystallography; Biophysics; Biochemistry; Organic chemistry; Biology; Copolymer; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001453972,0.0001868447,0.0001546636,0.00009920569,0.00009536489,0.0002417151,0.00009416752,0.0002813616,0.0007190134],"category_scores_gemma":[0.0002455199,0.0001037265,0.0001327214,0.00005312603,0.0001969316,0.0001607591,0.00007766539,0.0002230188,0.000316284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001390666,"about_ca_system_score_gemma":0.00008807326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000124663,"about_ca_topic_score_gemma":0.0001775222,"domain_scores_codex":[0.9999151,0.00001994584,0.000006160182,0.00001666085,0.00001619545,0.00002587982],"domain_scores_gemma":[0.9997258,0.00009832918,0.000058369,0.00001121218,0.00002077041,0.0000854923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001250713,0.00001362631,0.0008421822,0.000009556552,0.000003166202,0.00004097766,0.000004000962,0.00007768537,0.9979692,0.00002252984,0.000007977872,0.0008840179],"study_design_scores_gemma":[0.00003568765,0.0009122292,0.03098039,0.000009191168,0.00003352512,0.0008541218,0.00004063452,0.002374148,0.9637855,0.0001334683,0.0008271381,0.00001391566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991622,0.0001639706,0.0003299756,0.000007195413,0.000003303386,0.000004442785,0.00001682157,0.000004754386,0.0003072442],"genre_scores_gemma":[0.9992236,0.0001050278,0.0004356974,0.00002239867,0.000004452848,0.00000470959,0.00004185883,0.000003120928,0.0001592885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007190134,"threshold_uncertainty_score":0.002405345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01806973588916473,"score_gpt":0.2548330275931182,"score_spread":0.2367632917039534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}