{"id":"W2126044069","doi":"10.1128/aac.01053-10","title":"Deciphering the Mode of Action of the Synthetic Antimicrobial Peptide Bac8c","year":2011,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Advanced Foods and Materials Network","keywords":"Peptide; Escherichia coli; Mode of action; Biochemistry; Antimicrobial; Mechanism of action; Biology; Bacteria; Enterobacteriaceae; Cytoplasm; Cell membrane; Membrane; Biophysics; Chemistry; Microbiology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001397025,0.0003487745,0.0002683951,0.0001353132,0.00008609797,0.0004061481,0.0002189142,0.0005804957,0.0004877492],"category_scores_gemma":[0.0002409523,0.00009960666,0.0001983835,0.000078565,0.0002887958,0.0003997702,0.0002004769,0.0005817339,0.0002931539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001707435,"about_ca_system_score_gemma":0.0001517062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000206883,"about_ca_topic_score_gemma":0.0001493852,"domain_scores_codex":[0.9998983,0.00001563324,0.000008132762,0.00001872035,0.00003206772,0.00002710822],"domain_scores_gemma":[0.9998964,0.00002121261,0.00002211269,0.000008012938,0.0000300828,0.00002213066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003302739,0.000007246829,0.00007766121,0.00003598204,0.00000209329,0.00004185534,0.000006733248,0.00007846051,0.9986535,0.00006802531,0.000009645816,0.0009857083],"study_design_scores_gemma":[0.0000131739,0.0004964391,0.001806281,0.00001453503,0.00001102215,0.0005497588,0.00004737886,0.00274523,0.9913149,0.0001207257,0.002871675,0.00000895196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864697,0.004563608,0.006662935,0.0001613895,0.0000506013,0.0000863355,0.000171248,0.00005192156,0.001782332],"genre_scores_gemma":[0.9898953,0.002068975,0.006867549,0.0001492528,0.00001982324,0.00004588975,0.0002244459,0.00001015505,0.0007186543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005804957,"threshold_uncertainty_score":0.001631677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0247356762768138,"score_gpt":0.2414004795928854,"score_spread":0.2166648033160716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}