{"id":"W2126044069","doi":"10.1128/aac.01053-10","title":"Deciphering the Mode of Action of the Synthetic Antimicrobial Peptide Bac8c","year":2011,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Advanced Foods and Materials Network","keywords":"Peptide; Escherichia coli; Mode of action; Biochemistry; Antimicrobial; Mechanism of action; Biology; Bacteria; Enterobacteriaceae; Cytoplasm; Cell membrane; Membrane; Biophysics; Chemistry; Microbiology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001218271,0.0002471473,0.0003757516,0.00004902525,0.0002938612,0.00001513361,0.0004225565,0.0001839499,0.0004184355],"category_scores_gemma":[0.000012512,0.0001496243,0.0002423945,0.0001423882,0.0008769568,0.0001180231,0.0001428672,0.0002367478,0.00001264308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000142367,"about_ca_system_score_gemma":0.0000411178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009218018,"about_ca_topic_score_gemma":0.00007063901,"domain_scores_codex":[0.9988319,0.0001090608,0.0004167237,0.0002746244,0.00004708879,0.0003206379],"domain_scores_gemma":[0.9991068,0.00005397413,0.0003540266,0.0004015435,0.00006725494,0.00001641988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002698048,0.0002395299,0.007605446,0.00007339831,0.0002464471,5.954485e-7,0.002569659,0.00001014473,0.9716938,0.0002922329,0.01277579,0.004223201],"study_design_scores_gemma":[0.000904528,0.00006804737,0.01986265,0.0001658306,0.00007612306,0.00006155643,0.0003341971,0.000008121127,0.970287,0.00008393725,0.00795582,0.000192141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972039,0.00004492742,0.0001606768,0.000612111,0.0005404972,0.0002932973,0.00005575215,0.0000229938,0.001065884],"genre_scores_gemma":[0.9966272,0.0007028989,0.0002008518,0.001268659,0.00003744572,0.000003222428,0.000007069725,0.00003212664,0.001120523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0122572,"threshold_uncertainty_score":0.61015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0247356762768138,"score_gpt":0.2414004795928854,"score_spread":0.2166648033160716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}