{"id":"W2126100001","doi":"10.2337/diabetes.50.7.1515","title":"Hepatocyte Nuclear Factor-4α Involved in Type 1 Maturity-Onset Diabetes of the Young Is a Novel Target of AMP-Activated Protein Kinase","year":2001,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale","keywords":"Hepatocyte nuclear factors; AMPK; Endocrinology; Internal medicine; GLUT2; Protein kinase A; Hepatocyte nuclear factor 4; Biology; AMP-activated protein kinase; Transcription factor; Chemistry; Cell biology; Insulin; Glucose transporter; Kinase; Biochemistry; Nuclear receptor; Gene; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008216734,0.0002850045,0.0001758086,0.000138516,0.0001296025,0.0001260005,0.0001182727,0.0001420946,0.0007795403],"category_scores_gemma":[0.00005457403,0.00009444838,0.0002020878,0.00008874542,0.0001540593,0.00007365137,0.00009348291,0.0002472359,0.0002405004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000207476,"about_ca_system_score_gemma":0.0001452372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002427725,"about_ca_topic_score_gemma":0.0002943877,"domain_scores_codex":[0.999959,0.000006393815,0.000004065691,0.0000110356,0.00001073589,0.000008815658],"domain_scores_gemma":[0.9999491,0.000005224633,0.00002171672,0.000004905898,0.00000430744,0.00001480155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000296836,0.00002636414,0.0012232,0.00004506161,0.000006944877,0.0004869754,0.00001184866,0.00003452442,0.9950807,0.0001143512,0.00004562419,0.002627523],"study_design_scores_gemma":[0.0001041699,0.001215547,0.08141033,0.00001932449,0.00008918554,0.007977621,0.00008293747,0.0009392389,0.8959441,0.0003936428,0.0118124,0.00001155225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890884,0.005984159,0.003434572,0.0001196902,0.00005550007,0.00002510254,0.0001628597,0.00007871851,0.001050986],"genre_scores_gemma":[0.9936488,0.002223558,0.001568741,0.00006370216,0.00003179516,0.000027896,0.0004293841,0.000008845177,0.00199727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007795403,"threshold_uncertainty_score":0.002607822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02366667413157007,"score_gpt":0.242184726378533,"score_spread":0.2185180522469629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}