{"id":"W2126116995","doi":"10.1002/jps.21212","title":"Engineering of Pharmaceutical Materials: An Industrial Perspective","year":2007,"lang":"en","type":"review","venue":"Journal of Pharmaceutical Sciences","topic":"Crystallization and Solubility Studies","field":"Materials Science","cited_by":141,"is_retracted":false,"has_abstract":false,"ca_institutions":"Patheon (Canada)","funders":"","keywords":"Crystal engineering; Pharmaceutical industry; Quality by Design; Pharmaceutical technology; Pharmaceutical manufacturing; Computer science; Solid-state; Product (mathematics); Biochemical engineering; Pharmaceutical engineering; Product design; Manufacturing engineering; New product development; Nanotechnology; Engineering; Materials science; Chemistry; Business; Crystal structure; Mathematics; Medicine; Organic chemistry; Engineering physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.006461013,0.0003867351,0.001819078,0.000470757,0.0001721275,0.0001823741,0.001038187,0.0002785747,0.002612656],"category_scores_gemma":[0.001284912,0.0002635564,0.0003952339,0.0008553302,0.0009746183,0.0005119222,0.0002061915,0.0006191279,0.00002270516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002788843,"about_ca_system_score_gemma":0.0006473748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001215777,"about_ca_topic_score_gemma":0.00000173486,"domain_scores_codex":[0.9955165,0.0004880936,0.001791831,0.0004242582,0.001227151,0.000552126],"domain_scores_gemma":[0.9971188,0.0008088942,0.001011852,0.0001652177,0.0004677679,0.0004274654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006104119,0.002613967,0.00005089931,0.0141246,0.0008065919,0.0003458379,0.00272897,0.0003521655,0.04648601,0.03781207,0.001351924,0.8927166],"study_design_scores_gemma":[0.0005668135,0.0003654501,0.000002333666,0.002505322,0.0007309198,0.0002280974,0.0005269686,0.00009310053,0.005741788,0.0001028754,0.9887475,0.0003887698],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002291813,0.9934173,0.0003337318,0.0001119189,0.002960286,0.0003868244,0.00006888998,0.0000301612,0.0003990484],"genre_scores_gemma":[0.00212678,0.9953449,0.001106806,0.00005136084,0.001310961,0.000004148736,0.000001711951,0.00002442608,0.00002893305],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9873956,"threshold_uncertainty_score":0.9999816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3818760648291141,"score_gpt":0.5147735755130259,"score_spread":0.1328975106839118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}