{"id":"W2126122440","doi":"10.1128/iai.01346-09","title":"Substitution of the <i>Bordetella pertussis</i> Lipid A Phosphate Groups with Glucosamine Is Required for Robust NF-κB Activation and Release of Proinflammatory Cytokines in Cells Expressing Human but Not Murine Toll-Like Receptor 4-MD-2-CD14","year":2010,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Institut National de la Santé et de la Recherche Médicale","keywords":"Lipid A; Proinflammatory cytokine; Bordetella pertussis; TLR4; Biology; Pertussis toxin; HEK 293 cells; CD14; Lipopolysaccharide; Biochemistry; Inflammation; Receptor; Immunology; G protein; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003131371,0.0001681979,0.0002685674,0.0001241346,0.0004247117,0.00002152597,0.00006454403,0.0002067201,0.00006085202],"category_scores_gemma":[0.00009475721,0.0001214376,0.00005540193,0.0001684793,0.0002679488,0.0002731323,0.00006071178,0.0003197204,7.820394e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001987994,"about_ca_system_score_gemma":0.00004100953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001502904,"about_ca_topic_score_gemma":0.0005941491,"domain_scores_codex":[0.9991139,0.000155624,0.000364063,0.0001899682,0.00002358062,0.0001528382],"domain_scores_gemma":[0.9991183,0.0001086572,0.0003250117,0.0002551887,0.0001746306,0.00001823304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006513989,0.0001933536,0.0122357,0.0001269445,0.00003856552,4.253361e-8,0.0003301518,0.000007491731,0.9843559,0.0001220075,0.00007695784,0.001861472],"study_design_scores_gemma":[0.002080249,0.0002612614,0.06877667,0.000142029,0.00003603998,0.00001817425,0.00008186197,0.00002441546,0.9242181,0.0000178864,0.004210065,0.0001332747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984012,0.00008065346,0.0001865362,0.00007298614,0.0006530484,0.0005061416,0.00003142095,0.00002846929,0.00003952316],"genre_scores_gemma":[0.9993866,0.0001992459,0.00009526179,0.00002771822,0.00005232858,0.00004664218,0.00004656072,0.00001372877,0.000131904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06013785,"threshold_uncertainty_score":0.495208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01448149959112942,"score_gpt":0.226785001841104,"score_spread":0.2123035022499746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}