{"id":"W2126131588","doi":"10.1093/annonc/mdt042.16","title":"Small Molecular Subsets in Phase I Studies","year":2013,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Druggability; Medicine; Clinical trial; Personalized medicine; Precision medicine; Genomics; Drug development; Massive parallel sequencing; Bioinformatics; Computational biology; DNA sequencing; Internal medicine; Drug; Genome; Pathology; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009822433,0.0007234197,0.00191141,0.0005659811,0.0006645879,0.001712966,0.000664822,0.0009492049,0.006440009],"category_scores_gemma":[0.004851051,0.0003643199,0.001199194,0.0007845347,0.0006326754,0.001292428,0.001040127,0.002267287,0.001245575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009521581,"about_ca_system_score_gemma":0.00184034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002994136,"about_ca_topic_score_gemma":0.0006584988,"domain_scores_codex":[0.9972362,0.001972689,0.0001752636,0.0002175251,0.0001514014,0.0002469508],"domain_scores_gemma":[0.9963811,0.001604046,0.0004880126,0.0006055844,0.0003263722,0.0005948902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.3151782,0.007166581,0.02754129,0.00234466,0.002398923,0.0003728691,0.0004414712,0.003686938,0.03678463,0.006215138,0.01516424,0.5827051],"study_design_scores_gemma":[0.1731444,0.4212481,0.05793099,0.001578025,0.006322795,0.001439729,0.0006970975,0.004077374,0.04880423,0.02215409,0.2624779,0.0001251703],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8146467,0.101121,0.02233876,0.009961901,0.003230695,0.01326513,0.006320396,0.0004615388,0.02865388],"genre_scores_gemma":[0.9346814,0.01628348,0.01400528,0.004607288,0.001136989,0.01683983,0.005032845,0.0001882139,0.007224617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009822433,"threshold_uncertainty_score":0.05194658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09370844523778235,"score_gpt":0.3954109232011043,"score_spread":0.3017024779633219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}