{"id":"W2126139459","doi":"10.1136/ard.2009.111906","title":"Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls","year":2009,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":211,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Center for Research Resources; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health","keywords":"Haplotype; Linkage disequilibrium; Immunology; Allele; HLA-DRB1; Genetics; Medicine; Genotyping; Human leukocyte antigen; Major histocompatibility complex; Allele frequency; Genotype; Biology; Antigen; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000700053,0.0005031492,0.000530254,0.00125606,0.0007151098,0.0004718393,0.0003356175,0.0006193955,0.00185073],"category_scores_gemma":[0.001936223,0.0006346352,0.0004336933,0.001272396,0.0005724772,0.0003974076,0.0003247645,0.0004846345,0.0002409172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002382805,"about_ca_system_score_gemma":0.0002002153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007048884,"about_ca_topic_score_gemma":0.004641978,"domain_scores_codex":[0.9994054,0.0001929504,0.00006128802,0.0001661074,0.00008732727,0.00008700357],"domain_scores_gemma":[0.9991196,0.0003285256,0.0001957862,0.00008418629,0.00007855801,0.0001932543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009547562,0.00008508861,0.9945327,0.00001134265,0.0001311034,0.000263145,0.0002687544,0.00004776836,0.002134411,0.00004497251,0.0001108339,0.001415115],"study_design_scores_gemma":[0.00003155645,0.0001938415,0.9984618,0.000003061406,0.00007475978,0.00048492,0.0002619391,0.0001558,0.0001512084,0.00002894303,0.0001484288,0.000003641946],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999552,0.00008138257,0.00005206652,0.000007592822,0.000002831122,0.000003978345,0.0001121784,0.000001982586,0.0001859665],"genre_scores_gemma":[0.9993252,0.00008199514,0.00007585625,0.00001338964,0.000007827378,0.000008665059,0.0002587835,0.000003305059,0.0002250708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007048884,"threshold_uncertainty_score":0.01401567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1208579817604287,"score_gpt":0.3416424558652623,"score_spread":0.2207844741048336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}