{"id":"W2126146482","doi":"10.1016/j.bmcl.2009.10.083","title":"Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: Dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Pharmacophore; Structural isomer; Moiety; Stereochemistry; Salicylic acid; Diflunisal; Aspirin; Chemical synthesis; Biochemistry; In vitro; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001356115,0.0004453894,0.0009456153,0.0001579915,0.0001073106,0.000016958,0.00008614032,0.0002418514,0.00003577604],"category_scores_gemma":[0.0006102238,0.0003514853,0.0000783525,0.00030511,0.0008752751,0.0001418897,0.00005731823,0.0003395257,4.409644e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001274932,"about_ca_system_score_gemma":0.0002597206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003150419,"about_ca_topic_score_gemma":0.000001254638,"domain_scores_codex":[0.9972727,0.0001960913,0.0005563918,0.000632749,0.0009029295,0.0004390929],"domain_scores_gemma":[0.9983304,0.0002574987,0.0004910498,0.0003406897,0.0001560528,0.0004243428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007652888,0.0001460186,0.01028189,0.0008498537,0.0002055957,0.0001138374,0.0003131932,0.000001263134,0.9786108,0.000001100316,0.0000811256,0.008630021],"study_design_scores_gemma":[0.003155659,0.000314172,0.1239515,0.0007682252,0.0008267455,0.0004413697,0.0002369644,0.0001769757,0.8698095,0.000004432808,0.00001537171,0.0002990608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939554,0.003338615,0.00001492047,0.002001085,0.00006296389,0.0005303403,0.0000171941,0.00005348606,0.00002604027],"genre_scores_gemma":[0.9984165,0.0007051482,0.0001952156,0.0002648537,0.0003470425,0.00001960582,0.00001413551,0.00003565037,0.000001857033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1136697,"threshold_uncertainty_score":0.9998937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01991943262390834,"score_gpt":0.2591326117176704,"score_spread":0.2392131790937621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}