{"id":"W2126146482","doi":"10.1016/j.bmcl.2009.10.083","title":"Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: Dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Pharmacophore; Structural isomer; Moiety; Stereochemistry; Salicylic acid; Diflunisal; Aspirin; Chemical synthesis; Biochemistry; In vitro; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002900173,0.00038756,0.0003758852,0.0002793435,0.0001680747,0.0001793516,0.0003506007,0.0002841132,0.001158844],"category_scores_gemma":[0.0002233838,0.0001906951,0.0002926635,0.0002220545,0.000202296,0.0001982273,0.0001694059,0.0002510273,0.0004332398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000267231,"about_ca_system_score_gemma":0.0003675408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001125797,"about_ca_topic_score_gemma":0.001657835,"domain_scores_codex":[0.9998246,0.00003798693,0.00001899648,0.00002359641,0.00004571527,0.00004912199],"domain_scores_gemma":[0.9998846,0.00001324204,0.00003350394,0.00001488438,0.00002096007,0.0000328112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004303451,0.00007830074,0.00008424366,0.00004088231,0.000009534981,0.00007100207,0.00002219748,0.0002793218,0.9953832,0.0001464877,0.00004152679,0.003412967],"study_design_scores_gemma":[0.00008316879,0.001807312,0.0009651965,0.000004083227,0.00003081401,0.0001828743,0.00001524671,0.0003809874,0.9942714,0.00002229995,0.00222799,0.00000869703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879128,0.004535745,0.003859895,0.00007095677,0.00004023133,0.0001231501,0.0004170484,0.0000854197,0.002954604],"genre_scores_gemma":[0.9922003,0.002261045,0.002934014,0.00003446968,0.00001629694,0.00005024668,0.0004533277,0.00001632961,0.002034007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001158844,"threshold_uncertainty_score":0.003876686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01991943262390834,"score_gpt":0.2591326117176704,"score_spread":0.2392131790937621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}