{"id":"W2126147289","doi":"10.1126/science.1188454","title":"Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses","year":2010,"lang":"en","type":"article","venue":"Science","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":828,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Colonization; Immune system; Biology; Immunoglobulin A; Commensalism; Microbiology; Secretory IgA; Bacteria; Immunity; Immunology; Gut flora; Immunoglobulin G","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007978247,0.00005617797,0.00008637104,0.00004551603,0.0001359999,0.00001003274,0.0006190006,0.00006861009,0.00001122488],"category_scores_gemma":[0.0004637802,0.00004394634,0.00003388394,0.0003013173,0.0007444901,0.000005711252,0.0001935135,0.00007870856,0.000001760264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001100035,"about_ca_system_score_gemma":0.0004092492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005524352,"about_ca_topic_score_gemma":0.000244541,"domain_scores_codex":[0.9993483,0.00003453727,0.0001832898,0.00017474,0.00009993125,0.0001591914],"domain_scores_gemma":[0.9990675,0.00001968251,0.0001664029,0.0004868028,0.0002295413,0.00003009177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004609248,0.0000201059,0.001955039,0.00001768396,0.000002195423,1.177849e-7,0.00007160556,0.000002921557,0.9967642,0.0005684188,0.000451314,0.0001002364],"study_design_scores_gemma":[0.0001820906,0.0001045714,0.04355083,0.00001248497,0.000005842084,0.0000124374,0.00005806109,0.00003386951,0.9543653,0.000114159,0.001503084,0.00005732093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983471,0.0001214948,0.0001391856,0.0006964838,0.0002581904,0.0001263196,0.00005466765,0.00000251298,0.0002540127],"genre_scores_gemma":[0.9972764,0.00005434778,0.001631674,0.0001090389,0.00003135719,0.000001149415,0.00001396265,0.000004381736,0.0008777505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04239902,"threshold_uncertainty_score":0.2743105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006420386916115637,"score_gpt":0.259446110757982,"score_spread":0.2530257238418664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}