{"id":"W2126147289","doi":"10.1126/science.1188454","title":"Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses","year":2010,"lang":"en","type":"article","venue":"Science","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":828,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Colonization; Immune system; Biology; Immunoglobulin A; Commensalism; Microbiology; Secretory IgA; Bacteria; Immunity; Immunology; Gut flora; Immunoglobulin G","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002953711,0.0004668747,0.0003740473,0.0006996832,0.0001504929,0.0005160593,0.0003183939,0.0006245149,0.001354234],"category_scores_gemma":[0.0002972888,0.0003313724,0.0004223859,0.0002150896,0.0006098973,0.0004422695,0.000286572,0.002010008,0.0005091669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003252231,"about_ca_system_score_gemma":0.000137975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002956102,"about_ca_topic_score_gemma":0.0004073061,"domain_scores_codex":[0.9996735,0.0000402336,0.00001702945,0.00009852397,0.00005906442,0.0001116216],"domain_scores_gemma":[0.9995617,0.000060151,0.0001366949,0.00007901303,0.00002386602,0.0001385347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004338384,0.000063411,0.000459536,0.00002457719,0.000009066353,0.00009207313,0.00004039545,0.0001036822,0.9965095,0.0002606268,0.00008475254,0.001918556],"study_design_scores_gemma":[0.0001367725,0.002328897,0.02638254,0.00003598481,0.00005167009,0.0009644359,0.0001119076,0.002490877,0.9630809,0.001132897,0.003249146,0.00003400089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923266,0.00177538,0.002965459,0.0002277844,0.00006153233,0.00001745842,0.0004923946,0.0003032401,0.001830093],"genre_scores_gemma":[0.9938185,0.000806061,0.002248474,0.0001856422,0.00003124919,0.00003176076,0.0004013624,0.0001127076,0.002364245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001354234,"threshold_uncertainty_score":0.00453043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006420386916115637,"score_gpt":0.259446110757982,"score_spread":0.2530257238418664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}