{"id":"W2126152921","doi":"10.1371/journal.pgen.1003487","title":"Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"U.S. National Library of Medicine; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; Burroughs Wellcome Fund; National Human Genome Research Institute; National Institutes of Health; Versus Arthritis; Brigham and Women's Hospital","keywords":"Biology; Genome-wide association study; CD40; Allele; Genetics; Expression quantitative trait loci; Immunology; Single-nucleotide polymorphism; Gene; Genotype; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001908015,0.00021407,0.0004447224,0.0001089883,0.0001276186,0.00003163281,0.0003567177,0.0001044859,0.0005108906],"category_scores_gemma":[0.00007046694,0.0001532161,0.0001366443,0.0002784875,0.00028683,0.00003587529,0.0002970297,0.0003302787,0.00008306721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003917874,"about_ca_system_score_gemma":0.0001641921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009868845,"about_ca_topic_score_gemma":0.0003865495,"domain_scores_codex":[0.9977658,0.0001177725,0.0006299352,0.0002950124,0.0007193587,0.0004720717],"domain_scores_gemma":[0.9988271,0.00009753519,0.0001321288,0.0005141603,0.0002667366,0.00016235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004688634,0.0005861223,0.1690195,0.00031308,0.0002005372,0.00004125322,0.001878344,0.0003115962,0.8089187,0.0009823948,0.003803961,0.01389764],"study_design_scores_gemma":[0.001589071,0.0003463401,0.074608,0.001049507,0.00002555604,0.00003979678,0.000415481,0.002030228,0.9108043,0.003595358,0.005156926,0.0003394501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908465,0.005646717,0.000007040435,0.001348216,0.00007112193,0.0007095483,0.00004124522,0.00002083673,0.00130881],"genre_scores_gemma":[0.9942665,0.00172745,0.002299597,0.0003136688,0.000166043,0.00003963974,0.00002095891,0.00004096177,0.001125164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1018856,"threshold_uncertainty_score":0.6247973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03244712008688951,"score_gpt":0.2777513885037416,"score_spread":0.2453042684168521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}