{"id":"W2126152921","doi":"10.1371/journal.pgen.1003487","title":"Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"U.S. National Library of Medicine; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; Burroughs Wellcome Fund; National Human Genome Research Institute; National Institutes of Health; Versus Arthritis; Brigham and Women's Hospital","keywords":"Biology; Genome-wide association study; CD40; Allele; Genetics; Expression quantitative trait loci; Immunology; Single-nucleotide polymorphism; Gene; Genotype; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005682782,0.0004537608,0.0007102905,0.0004139362,0.0002052925,0.0006259719,0.0002803521,0.0005686688,0.002522744],"category_scores_gemma":[0.0005484108,0.0001981774,0.0004901231,0.0004196227,0.0003012142,0.0001511908,0.0003322031,0.0006627537,0.0007285491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003072672,"about_ca_system_score_gemma":0.000495505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007810594,"about_ca_topic_score_gemma":0.00191623,"domain_scores_codex":[0.9996771,0.00008051826,0.00001679253,0.00006099525,0.0001330151,0.00003162021],"domain_scores_gemma":[0.9997433,0.0001151391,0.00003439765,0.00003933868,0.000035482,0.00003227812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009002215,0.0003257954,0.01473415,0.0002730594,0.0003502337,0.0006995631,0.00006291352,0.00343227,0.8898025,0.002317192,0.003061043,0.08404111],"study_design_scores_gemma":[0.001164774,0.007318917,0.08941421,0.0001993277,0.001850606,0.006991289,0.0002140347,0.01602493,0.7345555,0.011413,0.1307344,0.000118953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8859221,0.03492415,0.05193334,0.004612296,0.0002778877,0.000454206,0.005378746,0.001558056,0.0149392],"genre_scores_gemma":[0.9570478,0.009666192,0.02580583,0.001584533,0.0001129126,0.0001635759,0.002104244,0.00007787319,0.003437101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002522744,"threshold_uncertainty_score":0.008439422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03244712008688951,"score_gpt":0.2777513885037416,"score_spread":0.2453042684168521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}