{"id":"W2126153147","doi":"10.1002/adhm.201500636","title":"Design and Characterization of a Multifunctional pH‐Triggered Peptide C8 for Selective Anticancer Activity","year":2015,"lang":"en","type":"article","venue":"Advanced Healthcare Materials","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Waterloo","funders":"Shanghai Jiao Tong University; Natural Sciences and Engineering Research Council of Canada; Shanghai Municipal Education Commission; Compute Canada","keywords":"Peptide; Drug delivery; Cytotoxicity; Chemistry; Amphiphile; Histidine; Liposome; Rational design; Biophysics; Membrane; Cationic polymerization; Cancer cell; Combinatorial chemistry; Drug; Amino acid; Nanotechnology; In vitro; Biochemistry; Materials science; Cancer; Biology; Pharmacology; Copolymer; Polymer; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002995297,0.00015788,0.0004145258,0.00006308012,0.0001299099,0.00001270243,0.00005522293,0.0001518199,0.00002650035],"category_scores_gemma":[0.00008502418,0.0001462425,0.00003190131,0.00006469332,0.0001366046,0.0002420795,0.00003309065,0.00007102083,0.000007827599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006413167,"about_ca_system_score_gemma":0.0001586482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001834931,"about_ca_topic_score_gemma":0.00001189599,"domain_scores_codex":[0.9989455,0.0002102463,0.0002703293,0.0002707056,0.00003253007,0.0002706745],"domain_scores_gemma":[0.9991366,0.0001565903,0.0002795972,0.0001117108,0.0002820276,0.00003348289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002469801,0.00005282523,0.00009823772,0.0001295757,0.00005061012,2.849599e-7,0.0003652093,0.00001071465,0.9917033,0.0003098173,0.0001723593,0.004637234],"study_design_scores_gemma":[0.001577826,0.0004703929,0.004132827,0.00006920719,0.00002067663,0.00001329868,0.0001073791,0.000006884227,0.9917669,0.0004344744,0.001250308,0.0001498348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817498,0.0001496087,0.01546281,0.0004441379,0.0007728137,0.0009076613,0.000455834,0.00004646129,0.00001091784],"genre_scores_gemma":[0.9960959,0.0001213681,0.002919378,0.0001389601,0.00006062462,0.0001077864,0.0002100053,0.00002166146,0.0003243127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01434615,"threshold_uncertainty_score":0.5963596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0377468823547266,"score_gpt":0.2917581461387264,"score_spread":0.2540112637839997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}