{"id":"W2126153147","doi":"10.1002/adhm.201500636","title":"Design and Characterization of a Multifunctional pH‐Triggered Peptide C8 for Selective Anticancer Activity","year":2015,"lang":"en","type":"article","venue":"Advanced Healthcare Materials","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Waterloo","funders":"Shanghai Jiao Tong University; Natural Sciences and Engineering Research Council of Canada; Shanghai Municipal Education Commission; Compute Canada","keywords":"Peptide; Drug delivery; Cytotoxicity; Chemistry; Amphiphile; Histidine; Liposome; Rational design; Biophysics; Membrane; Cationic polymerization; Cancer cell; Combinatorial chemistry; Drug; Amino acid; Nanotechnology; In vitro; Biochemistry; Materials science; Cancer; Biology; Pharmacology; Copolymer; Polymer; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001461646,0.0001749964,0.0001247159,0.0001235515,0.0001204937,0.0001418005,0.0001723123,0.0002952573,0.0004004912],"category_scores_gemma":[0.0002476559,0.00007661839,0.0000915112,0.00009005753,0.0001232065,0.0001248241,0.0001047366,0.0001858166,0.0001755777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001813574,"about_ca_system_score_gemma":0.0001854544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002976504,"about_ca_topic_score_gemma":0.0002151342,"domain_scores_codex":[0.9999156,0.00001148331,0.000007208204,0.00001840358,0.00003290222,0.00001441961],"domain_scores_gemma":[0.9998667,0.00001978861,0.00003581645,0.00001153841,0.00004384111,0.00002225407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002663206,0.000008963032,0.00009184273,0.00001687647,8.607665e-7,0.00002474874,0.000007656514,0.0001904331,0.9986774,0.00002848269,0.00000985409,0.000916142],"study_design_scores_gemma":[0.000008414998,0.0002234095,0.0006671174,0.000002226501,0.000003846594,0.00009410937,0.000006959379,0.001946984,0.9958871,0.00001432974,0.001142422,0.000003111077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946109,0.000322686,0.004299274,0.00002829636,0.000005710182,0.00005164541,0.00007461292,0.00002430171,0.0005825442],"genre_scores_gemma":[0.9894319,0.0001786398,0.009239834,0.0000174428,0.000004248341,0.00005003882,0.0001420045,0.00001174384,0.0009242076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004004912,"threshold_uncertainty_score":0.001339734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0377468823547266,"score_gpt":0.2917581461387264,"score_spread":0.2540112637839997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}