{"id":"W2126167719","doi":"10.1021/bi050607y","title":"Purification and Biochemical Characterization of a Pyruvate-Specific Class II Aldolase, HpaI","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"University of Guelph","keywords":"Aldolase A; Chemistry; Pyruvate decarboxylase; Enzyme; Active site; Stereochemistry; Aldolase B; Biochemistry; Fructose-bisphosphate aldolase; Enzyme kinetics; Oxalate; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009477135,0.0001645256,0.0001534137,0.00002610954,0.00006362596,0.00001317843,0.0001401115,0.000251293,0.00002946933],"category_scores_gemma":[0.00003189845,0.0001677445,0.00006246615,0.00008211547,0.0001301057,0.000006511848,0.0001122559,0.0000742933,0.000004128492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001170583,"about_ca_system_score_gemma":0.00003971995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001467797,"about_ca_topic_score_gemma":2.5082e-7,"domain_scores_codex":[0.9990482,0.00001358225,0.0002636748,0.0003721946,0.0001170693,0.0001852781],"domain_scores_gemma":[0.9993118,0.00000370541,0.0001366047,0.0003634597,0.00008787123,0.00009655631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004523803,0.00008039334,0.0002016985,0.00003100306,0.00001657549,2.31944e-7,0.0000283844,7.498062e-7,0.9927724,0.00007834553,0.002300334,0.004444616],"study_design_scores_gemma":[0.0003336555,0.00003311997,0.001978703,0.0000118329,0.00001174995,0.00000854334,0.00001915359,0.00003848852,0.8557683,0.000004224763,0.1416356,0.0001565662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962381,0.002243544,0.0003976664,0.000316569,0.00005961018,0.0001016263,0.00005837804,0.00001680377,0.0005676859],"genre_scores_gemma":[0.9949625,0.001226136,0.001010356,0.0001341626,0.0005896563,0.00001751215,0.000731652,0.00002144286,0.001306621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1393353,"threshold_uncertainty_score":0.684042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006364143452886494,"score_gpt":0.2081581580851488,"score_spread":0.2017940146322623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}