{"id":"W2126186300","doi":"10.1084/jem.191.12.2197","title":"Mitochondrial Basis for Immune Deficiency","year":2000,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Immune system; Thymocyte; Purine nucleoside phosphorylase; Mitochondrial DNA; Apoptosis; Biology; Mitochondrion; DNA damage; Knockout mouse; Immunodeficiency; T cell; Programmed cell death; Immunology; Molecular biology; Cell biology; Purine; DNA; Genetics; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000289651,0.00009104999,0.0001409759,0.00002365201,0.00007540233,0.000004553667,0.0003026208,0.00005621744,0.0003948403],"category_scores_gemma":[0.0001120346,0.00005008163,0.0001030743,0.00005793454,0.0002070584,0.000002525758,0.00003401026,0.00009530218,0.000004317636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001284895,"about_ca_system_score_gemma":0.00003516792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001149427,"about_ca_topic_score_gemma":3.87958e-7,"domain_scores_codex":[0.9992014,0.00005329059,0.0002679348,0.00008682726,0.0002195067,0.0001710472],"domain_scores_gemma":[0.9995619,0.00002901895,0.00007750819,0.0001737892,0.00007471997,0.00008308513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001093523,0.00008287137,0.00000318993,0.000003821229,0.00002621524,0.000001750255,0.000127127,0.0000024128,0.9897441,0.00001983702,0.006253991,0.002641195],"study_design_scores_gemma":[0.001360673,0.002199762,0.00003016267,0.00003036259,0.00002423519,0.000141491,0.0003263507,0.000005168204,0.9650427,0.00003865636,0.03074033,0.00006011077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744889,0.02097784,0.0006392108,0.001525524,0.0002387277,0.0001929691,0.00000299337,0.000001989653,0.001931906],"genre_scores_gemma":[0.9968824,0.0004775433,0.0004211547,0.0003786281,0.0009383687,0.000006605646,0.000007027519,0.00001229495,0.0008759729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02470137,"threshold_uncertainty_score":0.4323224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531170874479407,"score_gpt":0.3144923472579272,"score_spread":0.2991806385131331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}