{"id":"W2126186300","doi":"10.1084/jem.191.12.2197","title":"Mitochondrial Basis for Immune Deficiency","year":2000,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Immune system; Thymocyte; Purine nucleoside phosphorylase; Mitochondrial DNA; Apoptosis; Biology; Mitochondrion; DNA damage; Knockout mouse; Immunodeficiency; T cell; Programmed cell death; Immunology; Molecular biology; Cell biology; Purine; DNA; Genetics; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002202877,0.000415899,0.0002324697,0.0004547275,0.0002364422,0.0003041388,0.0004637006,0.0007225007,0.00393431],"category_scores_gemma":[0.0004404861,0.00007772748,0.0001910014,0.0001392233,0.000512231,0.0002704529,0.0005772565,0.0006109311,0.0005215968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003184155,"about_ca_system_score_gemma":0.0001953323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000169998,"about_ca_topic_score_gemma":0.0001231018,"domain_scores_codex":[0.9998497,0.00003208378,0.0000176653,0.00003969139,0.0000274223,0.00003351504],"domain_scores_gemma":[0.9996932,0.00005703613,0.00008939867,0.00002785573,0.0000465115,0.000086104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001879526,0.0003913471,0.01595748,0.001223037,0.0001394213,0.02296991,0.0002272625,0.0008797087,0.8690336,0.02930982,0.004678709,0.05331014],"study_design_scores_gemma":[0.001025561,0.004094223,0.06952188,0.000943959,0.0005941362,0.2302587,0.0005217411,0.007347625,0.5076205,0.02364307,0.1543363,0.00009232141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9079325,0.04366414,0.01994877,0.005101172,0.0007446944,0.0001987709,0.001230295,0.000670553,0.02050915],"genre_scores_gemma":[0.9887434,0.006682354,0.001901363,0.000392831,0.0001333446,0.00004433122,0.0003201821,0.00002773415,0.001754415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00393431,"threshold_uncertainty_score":0.0131616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531170874479407,"score_gpt":0.3144923472579272,"score_spread":0.2991806385131331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}