{"id":"W2126186643","doi":"10.1007/s11154-013-9282-4","title":"Role of protein tyrosine phosphatases in the modulation of insulin signaling and their implication in the pathogenesis of obesity-linked insulin resistance","year":2013,"lang":"en","type":"review","venue":"Reviews in Endocrine and Metabolic Disorders","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut Universitaire de Cardiologie et de Pneumologie de Québec","funders":"Canadian Institutes of Health Research","keywords":"Insulin resistance; Insulin receptor; Protein tyrosine phosphatase; Insulin; Tyrosine phosphorylation; Proto-oncogene tyrosine-protein kinase Src; Effector; Insulin receptor substrate; GRB10; SH2 domain; Biology; Signal transduction; Tyrosine; Cell biology; Endocrinology; Internal medicine; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001100974,0.000349041,0.00138607,0.0001625525,0.00002409266,0.00001118691,0.0004302158,0.0001005613,0.000002626587],"category_scores_gemma":[0.0004782887,0.0002042739,0.0001755172,0.0006473229,0.0001490324,0.00001772122,0.0001191434,0.0001674355,3.120003e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006543482,"about_ca_system_score_gemma":0.00007431281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003855899,"about_ca_topic_score_gemma":0.0003506356,"domain_scores_codex":[0.9971522,0.0008125532,0.001289204,0.0003974499,0.0001383082,0.0002102639],"domain_scores_gemma":[0.9982871,0.0001113763,0.0008887482,0.0006386825,0.00005194533,0.00002211692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002544551,0.0002354851,0.0002056157,0.006721429,0.00002531289,3.288395e-7,0.000146186,0.000006013579,0.006999599,0.001702988,0.00001089756,0.9839207],"study_design_scores_gemma":[0.0009590605,0.000124187,0.005162188,0.006592375,0.0002019857,0.000007931217,0.0002574263,0.00001093933,0.01508048,0.001312021,0.9698853,0.0004060547],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02814498,0.9679366,0.00002506366,0.00003262939,0.000008555483,0.003636511,0.0001958811,0.000001645049,0.00001812273],"genre_scores_gemma":[0.08141781,0.9166092,0.0004552344,0.00002180188,0.00002126062,0.00108106,0.0003695536,0.0000203095,0.000003719347],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9835147,"threshold_uncertainty_score":0.833005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01748663360422857,"score_gpt":0.2806110011778634,"score_spread":0.2631243675736348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}