{"id":"W2126216994","doi":"10.1002/smll.201501056","title":"Cancer‐Cell‐Specific Nuclear‐Targeted Drug Delivery by Dual‐Ligand‐Modified Mesoporous Silica Nanoparticles","year":2015,"lang":"en","type":"article","venue":"Small","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Australian Research Council; Natural Sciences and Engineering Research Council of Canada","keywords":"Mesoporous silica; Nanoparticle; Ligand (biochemistry); Nanotechnology; Drug delivery; Materials science; Targeted drug delivery; Dual (grammatical number); Mesoporous material; Drug; Combinatorial chemistry; Chemistry; Organic chemistry; Pharmacology; Biochemistry; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001606145,0.0002289395,0.0001945731,0.0000233473,0.00008803463,0.00005517851,0.0002858889,0.0001524069,0.00006492044],"category_scores_gemma":[0.00001651846,0.0002194213,0.000100731,0.00007204635,0.0000874439,0.000009511226,0.0001525118,0.0001016894,0.0001337905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004761073,"about_ca_system_score_gemma":0.0001139656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006941296,"about_ca_topic_score_gemma":0.0004105306,"domain_scores_codex":[0.9986024,0.00006587248,0.0002587041,0.0004818284,0.0001606729,0.000430461],"domain_scores_gemma":[0.9990508,0.000008640796,0.0000897151,0.0004271166,0.0001716033,0.0002521283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001720697,0.00009088926,0.00027613,0.0000071297,0.0000377836,0.000009171357,0.0002292928,0.0000444331,0.8085826,0.00001421121,0.1891143,0.001422026],"study_design_scores_gemma":[0.0008325877,0.0002718934,0.0001518692,0.00001017106,0.00002407451,0.000008190545,0.0005878178,0.00007996423,0.8909127,0.00006072436,0.1067258,0.0003341256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811465,0.01533537,0.00001452866,0.0002583647,0.0003380141,0.000149199,0.00006588471,0.00004545087,0.002646707],"genre_scores_gemma":[0.9941117,0.001936041,0.0001450916,0.0006595326,0.0002539509,0.00002467162,0.0001347806,0.00004230755,0.002691955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08238842,"threshold_uncertainty_score":0.8947743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01969263666030506,"score_gpt":0.2254223159383137,"score_spread":0.2057296792780086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}