{"id":"W2126243275","doi":"10.1042/bj20021818","title":"Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism","year":2003,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Dirección General de Enseñanza Superior e Investigación Científica; Canadian Institutes of Health Research; European Commission","keywords":"Aldose reductase; Aldo-keto reductase; Aldehyde Reductase; Biochemistry; Reductase; Retinal; Aldose reductase inhibitor; Biology; NAD+ kinase; 7-Dehydrocholesterol reductase; Retinaldehyde; Enzyme; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000900609,0.0005603401,0.0005564691,0.0001555802,0.0006775293,0.0001645377,0.0004117489,0.0003408663,0.0001140819],"category_scores_gemma":[0.001150888,0.0005022759,0.0003064535,0.0002003127,0.000974532,0.00001176168,0.0001617759,0.0005349244,0.000004844921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005264759,"about_ca_system_score_gemma":0.0002594234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002012505,"about_ca_topic_score_gemma":0.000002482978,"domain_scores_codex":[0.996817,0.0002505999,0.0008809997,0.0009295986,0.00031179,0.000810007],"domain_scores_gemma":[0.9976873,0.00003844441,0.0005871889,0.0005707648,0.0004240626,0.0006921833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002137035,0.0003573886,0.0001205525,0.00007028363,0.0001421298,0.0001017255,0.0000475201,0.000006157369,0.9750428,0.001219332,0.022489,0.0001894525],"study_design_scores_gemma":[0.002317408,0.0005310317,0.0001614237,0.0001340764,0.0002051122,0.004611096,0.000425335,0.000004678718,0.9699031,0.001421307,0.01962382,0.000661644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901385,0.007399913,0.0001290291,0.0008702823,0.0003259073,0.0004902559,0.0001934672,0.00003320848,0.0004194423],"genre_scores_gemma":[0.9893437,0.0002357381,0.00781546,0.0002839376,0.001457445,0.00005721111,0.0003690628,0.0000755839,0.0003618608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007686431,"threshold_uncertainty_score":0.9997429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0198587402058647,"score_gpt":0.278702999422679,"score_spread":0.2588442592168143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}