{"id":"W2126243275","doi":"10.1042/bj20021818","title":"Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism","year":2003,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Dirección General de Enseñanza Superior e Investigación Científica; Canadian Institutes of Health Research; European Commission","keywords":"Aldose reductase; Aldo-keto reductase; Aldehyde Reductase; Biochemistry; Reductase; Retinal; Aldose reductase inhibitor; Biology; NAD+ kinase; 7-Dehydrocholesterol reductase; Retinaldehyde; Enzyme; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001622753,0.0003301543,0.0002701349,0.0001333445,0.00008019385,0.0003192334,0.000121934,0.0002055115,0.001796484],"category_scores_gemma":[0.0002605009,0.00009380555,0.0002479954,0.0001862807,0.0001824103,0.0002215283,0.0001425491,0.0003217437,0.0005955013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001656049,"about_ca_system_score_gemma":0.00007737878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005628794,"about_ca_topic_score_gemma":0.0005038929,"domain_scores_codex":[0.9998446,0.00002885875,0.000012435,0.00004373378,0.00003684675,0.00003357793],"domain_scores_gemma":[0.9999005,0.00001918584,0.0000218014,0.00002096517,0.00001502021,0.00002257899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006297901,0.00005113722,0.002226193,0.0000846595,0.00002983542,0.0002012076,0.00003280178,0.00007336563,0.9862461,0.0003217797,0.0001409973,0.009962142],"study_design_scores_gemma":[0.00005102452,0.0008848166,0.03384867,0.000009697071,0.00008497994,0.003992795,0.00006393027,0.0004671201,0.9436435,0.0003165088,0.01662354,0.00001348677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709099,0.01469954,0.009462711,0.0001934025,0.00008824953,0.00004862878,0.0007798812,0.0001640362,0.003653766],"genre_scores_gemma":[0.9855807,0.003224574,0.003928987,0.00006748263,0.00003046787,0.00001964235,0.00209906,0.00002288206,0.005026118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001796484,"threshold_uncertainty_score":0.006009817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0198587402058647,"score_gpt":0.278702999422679,"score_spread":0.2588442592168143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}