{"id":"W2126279424","doi":"10.1128/iai.01504-14","title":"Phosphoethanolamine Decoration of Neisseria gonorrhoeae Lipid A Plays a Dual Immunostimulatory and Protective Role during Experimental Genital Tract Infection","year":2014,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Vector Institute; National Institute of Allergy and Infectious Diseases; U.S. Department of Veterans Affairs","keywords":"Biology; Microbiology; Lipid A; Neisseria gonorrhoeae; TLR2; TLR4; Proinflammatory cytokine; Innate immune system; Cathelicidin; Antimicrobial peptides; Inflammation; Immunology; Lipopolysaccharide; Immune system; Antimicrobial","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009025862,0.0002798665,0.0001262727,0.0001186234,0.000113372,0.0001710877,0.0001214208,0.000205552,0.0006070168],"category_scores_gemma":[0.00008029027,0.00008191183,0.000180718,0.00007464465,0.0001570228,0.0001585898,0.0001818266,0.0002849232,0.0001186873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001362083,"about_ca_system_score_gemma":0.0001105087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004854223,"about_ca_topic_score_gemma":0.0006876705,"domain_scores_codex":[0.9999037,0.00001802758,0.000009817495,0.00001700613,0.00002457436,0.00002697304],"domain_scores_gemma":[0.9999431,0.000007859679,0.00001711001,0.000008492975,0.000008183075,0.00001507263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004653139,0.000007957402,0.00006291849,0.000009942579,0.000001218864,0.00001912953,0.000005525705,0.000007605261,0.9996161,0.00001137021,0.000002632492,0.0002091812],"study_design_scores_gemma":[0.000005582462,0.0002777933,0.002874807,0.000003850329,0.000006623789,0.0001202137,0.00001867326,0.0001417939,0.9959683,0.00001447403,0.0005654875,0.000002449748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985034,0.0003253756,0.0006953586,0.0000303782,0.00001033319,0.000008812033,0.00006512981,0.00001212892,0.0003489928],"genre_scores_gemma":[0.9967403,0.0004787214,0.001622639,0.00003011515,0.000006659191,0.00001657356,0.0001813665,0.000007859634,0.0009157943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006070168,"threshold_uncertainty_score":0.002030671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01064598166602327,"score_gpt":0.2643679944926059,"score_spread":0.2537220128265826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}