{"id":"W2126281471","doi":"10.1128/mcb.01265-06","title":"Differential Regulation of B-Raf Isoforms by Phosphorylation and AutoinhibitoryMechanisms","year":2006,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"Institut National de la Santé et de la Recherche Médicale; Institut National Du Cancer; Centre National de la Recherche Scientifique; Association pour la Recherche sur le Cancer","keywords":"Gene isoform; Phosphorylation; Biology; Exon; Alternative splicing; RNA splicing; Kinase; Protein kinase domain; Mutation; Molecular biology; Cell biology; Biochemistry; Gene; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001610581,0.000281536,0.0001358766,0.0001593033,0.000156035,0.0002867614,0.0001593363,0.0002294356,0.0007393675],"category_scores_gemma":[0.0001037781,0.0001749519,0.000274584,0.00008370978,0.000218137,0.0001894389,0.000201854,0.0004399683,0.0002750595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001678029,"about_ca_system_score_gemma":0.0001057022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002821207,"about_ca_topic_score_gemma":0.0004445949,"domain_scores_codex":[0.9998103,0.00003828975,0.00001599722,0.00003638782,0.00004916028,0.00004993397],"domain_scores_gemma":[0.9999144,0.00001633329,0.00002758566,0.00001250432,0.0000110086,0.00001828593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004209629,0.00001109618,0.0001298109,0.000008627797,0.000002361779,0.00002283965,0.000007460422,0.00002368949,0.9994215,0.00005060606,0.000005336179,0.0002746898],"study_design_scores_gemma":[0.00001568246,0.0001521289,0.009367993,0.000004925071,0.00001126549,0.0003514656,0.00002756103,0.0009402766,0.9882089,0.00006852463,0.0008455584,0.000005628203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978388,0.0006254351,0.0008138939,0.00002383966,0.000007387041,0.000008743497,0.00005806408,0.00001479504,0.0006091809],"genre_scores_gemma":[0.9977918,0.0004620095,0.0008906553,0.00002306679,0.000003649676,0.00001850286,0.0001237882,0.000006598576,0.0006798396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007393675,"threshold_uncertainty_score":0.002473414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002355465144577604,"score_gpt":0.17373805012108,"score_spread":0.1713825849765024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}