{"id":"W2126308493","doi":"10.1021/bi0268450","title":"Real-Time Monitoring of the Interactions of Two-Stranded <i>de Novo</i> Designed Coiled-Coils:  Effect of Chain Length on the Kinetic and Thermodynamic Constants of Binding","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Biotechnology Research Institute; University of Alberta","funders":"","keywords":"Heptad repeat; Coiled coil; Chemistry; Electromagnetic coil; Crystallography; Affinities; Biophysics; Stereochemistry; Peptide sequence; Biochemistry; Physics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003092428,0.0002685871,0.0002585447,0.00006974509,0.00009400318,0.0002420435,0.0001768667,0.0002283166,0.0003207267],"category_scores_gemma":[0.0003998934,0.0001071835,0.000143805,0.0001032071,0.0001826142,0.0002345196,0.0001381655,0.0003801943,0.0001782915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002603197,"about_ca_system_score_gemma":0.00009914233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002407996,"about_ca_topic_score_gemma":0.000289928,"domain_scores_codex":[0.999749,0.00006667974,0.00001819924,0.00006227332,0.00006167268,0.00004220219],"domain_scores_gemma":[0.9996985,0.0000946582,0.0000811663,0.0000163104,0.00005371727,0.00005559544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006275155,0.00001529113,0.0002659868,0.00001494485,0.000004206165,0.00000866265,0.00001006677,0.0002079775,0.9987348,0.00001934647,0.000008783873,0.0006472723],"study_design_scores_gemma":[0.000003429235,0.00009936879,0.001083726,0.000001316862,0.00000444722,0.00002277514,0.00001235298,0.002797315,0.9957419,0.000009252217,0.0002195916,0.000004546986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937114,0.0002581266,0.005731735,0.00001568065,0.000007235883,0.00001087623,0.00005141126,0.00002908662,0.0001844208],"genre_scores_gemma":[0.9916281,0.0001428911,0.007642429,0.00002911266,0.000003193205,0.00001937269,0.0001216361,0.00001263484,0.0004006159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003207267,"threshold_uncertainty_score":0.001888812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01507545255576313,"score_gpt":0.2995554536128872,"score_spread":0.284480001057124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}