{"id":"W2126338026","doi":"10.1128/jvi.00433-09","title":"Human Immunodeficiency Virus Type 1 Escapes from Interleukin-2-Producing CD4 <sup>+</sup> T-Cell Responses without High-Frequency Fixation of Mutations","year":2009,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Maple Leaf Medical Clinic; Mount Sinai Hospital; University of Toronto","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Ontario HIV Treatment Network","keywords":"Biology; Epitope; Virology; clone (Java method); Immune system; Major histocompatibility complex; T cell; Antigen; Virus; HIV Antigens; Peripheral blood mononuclear cell; Immunology; Viral disease; Genetics; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001013074,0.0001859389,0.0001098445,0.00007062472,0.0001000194,0.0002130744,0.0001069703,0.0001748812,0.0006205258],"category_scores_gemma":[0.000197691,0.00008516399,0.0001223488,0.00005069613,0.0001273947,0.00009826559,0.0001071331,0.00029889,0.0002233582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001303186,"about_ca_system_score_gemma":0.00008407618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002712619,"about_ca_topic_score_gemma":0.0004102481,"domain_scores_codex":[0.9999309,0.00001085995,0.00000471456,0.00001513543,0.00001390904,0.00002441837],"domain_scores_gemma":[0.9998971,0.00002461086,0.0000247754,0.00001793698,0.00001085004,0.00002471838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001903626,0.0000441092,0.007746099,0.00002153647,0.000008605369,0.0003906256,0.00006508805,0.00007550273,0.9866346,0.00007525313,0.0000653631,0.004682914],"study_design_scores_gemma":[0.0001129502,0.003613984,0.3145943,0.00003469202,0.0000653935,0.01725223,0.0002613192,0.003174624,0.6545016,0.0004363653,0.005932842,0.00001959434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993678,0.0001152472,0.0001990649,0.00000763511,0.000001912053,0.000004198708,0.00002196792,0.000007722981,0.0002745051],"genre_scores_gemma":[0.998693,0.00007005905,0.0003589128,0.00002927897,0.000004358098,0.000007150577,0.0001610376,0.000004292423,0.0006718774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006205258,"threshold_uncertainty_score":0.002075851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0170796498925711,"score_gpt":0.2878692005720869,"score_spread":0.2707895506795158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}