{"id":"W2126350253","doi":"10.1074/jbc.m412753200","title":"Crystal Structure of a Novel Shikimate Dehydrogenase from Haemophilus influenzae","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Argonne National Laboratory; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Biological and Environmental Research; National Institutes of Health; U.S. Department of Energy","keywords":"Shikimate pathway; Aromatic amino acids; Stereochemistry; Biochemistry; Chemistry; Bifunctional; Dehydrogenase; Enzyme; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002046596,0.0004308796,0.000723897,0.0001819647,0.0004398132,0.000658054,0.0008444879,0.0004930809,0.002659732],"category_scores_gemma":[0.0004542397,0.0002589658,0.0002635794,0.0004634722,0.0001674976,0.0003274129,0.000252843,0.001135417,0.0007373695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009302021,"about_ca_system_score_gemma":0.0008823675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007820879,"about_ca_topic_score_gemma":0.008138881,"domain_scores_codex":[0.999848,0.00001679444,0.000006204405,0.00003316853,0.00006865938,0.00002716395],"domain_scores_gemma":[0.99975,0.00003619487,0.00002838736,0.000009655383,0.0001102656,0.00006558114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002268654,0.0006766267,0.01698734,0.002020299,0.000533422,0.003145982,0.000883413,0.009361308,0.8782093,0.003067574,0.04243234,0.04041374],"study_design_scores_gemma":[0.002412204,0.002085822,0.1621151,0.000403715,0.0008400496,0.007267064,0.002464402,0.1640176,0.3561086,0.003301296,0.2985825,0.0004016841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9505112,0.01452157,0.008469626,0.002226808,0.0004532859,0.0001285276,0.0097774,0.0008750261,0.0130366],"genre_scores_gemma":[0.913541,0.00691794,0.01751761,0.0006998024,0.00007474728,0.0001548191,0.04964548,0.0002462534,0.0112024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007820879,"threshold_uncertainty_score":0.01555073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135135242712641,"score_gpt":0.2481299604832953,"score_spread":0.2346164362120312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}