{"id":"W2126414664","doi":"10.1128/aac.44.4.821-826.2000","title":"Single-Dose Pharmacokinetics of Amprenavir, a Human Immunodeficiency Virus Type 1 Protease Inhibitor, in Subjects with Normal or Impaired Hepatic Function","year":2000,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"Amprenavir; Protease inhibitor (pharmacology); Pharmacokinetics; Enzyme inhibitor; Pharmacology; Ritonavir; Protease; Medicine; Virology; Human immunodeficiency virus (HIV); Biology; Enzyme; Viral load; Antiretroviral therapy; Biochemistry; HIV-1 protease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006591388,0.0002083881,0.0002966649,0.0001064009,0.00007359546,0.00001904601,0.00004746199,0.00006207707,0.0007972592],"category_scores_gemma":[0.000002211495,0.0001448976,0.00004155372,0.000302916,0.00008133901,0.00008037846,0.00001088635,0.00009444343,0.00001128598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004557567,"about_ca_system_score_gemma":0.00008740385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000158287,"about_ca_topic_score_gemma":0.00004994673,"domain_scores_codex":[0.9990496,0.00002538464,0.0002940375,0.0002401874,0.0001501847,0.0002406007],"domain_scores_gemma":[0.9996591,0.000007850425,0.00008007258,0.0001388172,0.00004808459,0.0000660666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01611485,0.006166089,0.1852748,0.0003570701,0.0003598682,0.0002091581,0.003584841,0.0000125879,0.7149332,0.000002848775,0.00288585,0.0700988],"study_design_scores_gemma":[0.0403366,0.005415475,0.2472048,0.0012453,0.0003954093,0.0001735325,0.0001220069,0.0002680445,0.6848949,0.00001259883,0.01913978,0.0007915078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985278,0.00004925834,0.000005013941,0.0003005857,0.0000378034,0.0006892276,0.00000642962,0.00002940933,0.0003545295],"genre_scores_gemma":[0.9947958,0.0004509259,0.0002847589,0.00069272,0.00003633462,0.00001229975,0.00005434018,0.00003014349,0.003642681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0693073,"threshold_uncertainty_score":0.8729429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01668858334773212,"score_gpt":0.2574691009100379,"score_spread":0.2407805175623058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}