{"id":"W2126428397","doi":"10.1186/1475-2867-11-44","title":"Multi-tyrosine kinase inhibitors in preclinical studies for pediatric CNS AT/RT: Evidence for synergy with Topoisomerase-I inhibition","year":2011,"lang":"en","type":"article","venue":"Cancer Cell International","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Alberta Children's Hospital","funders":"Canadian Institutes of Health Research; Alberta Children's Hospital Foundation; American College Health Foundation; Alberta Children's Hospital Research Institute; Children's Hospital Foundation","keywords":"Topoisomerase; Medicine; Tyrosine kinase; Pharmacology; Tyrosine-kinase inhibitor; Topoisomerase inhibitor; Kinase; Cancer research; Neuroscience; Enzyme; Chemistry; Biology; Internal medicine; Cancer; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006274119,0.0006349782,0.0008197856,0.0003720681,0.0001499369,0.00041181,0.0004379844,0.0002398361,0.002643161],"category_scores_gemma":[0.0003270681,0.000172437,0.000512964,0.0003167094,0.0002286424,0.0003359554,0.0001489614,0.001170538,0.0004679352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004189186,"about_ca_system_score_gemma":0.000660472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004656319,"about_ca_topic_score_gemma":0.001835782,"domain_scores_codex":[0.9998153,0.00005962111,0.00001979563,0.00002773631,0.00003853462,0.00003912563],"domain_scores_gemma":[0.9996406,0.00007447864,0.0001024777,0.00003294773,0.00005235191,0.00009713392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01230627,0.006165321,0.003699747,0.001801627,0.0005077489,0.0005786268,0.0001594331,0.002515466,0.8942014,0.0003400597,0.001139132,0.07658507],"study_design_scores_gemma":[0.003072907,0.1352911,0.01705129,0.0001727514,0.001078838,0.002986193,0.0001010955,0.001987627,0.8226334,0.0001397696,0.01545377,0.00003125426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9679354,0.02454889,0.002668298,0.0003316343,0.0001124162,0.0005314169,0.0009864336,0.0001177342,0.002767832],"genre_scores_gemma":[0.974985,0.01733492,0.004205822,0.00009699322,0.00006161279,0.0002499987,0.001733732,0.00003058478,0.001301421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002643161,"threshold_uncertainty_score":0.008842289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1254896639447224,"score_gpt":0.3809214279352885,"score_spread":0.2554317639905661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}