{"id":"W2126438274","doi":"10.1186/s13059-015-0698-x","title":"Dynamics of gene silencing during X inactivation using allele-specific RNA-seq","year":2015,"lang":"en","type":"article","venue":"Genome biology","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Seventh Framework Programme; Medical Research Council; European Parliament; European Commission; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust","keywords":"Biology; RNA-Seq; Genetics; Gene silencing; Human genetics; Gene; Allele; Computational biology; Genomics; Gene expression; Transcriptome; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004263968,0.0002283725,0.0003917741,0.0004006628,0.0002938795,0.0006047952,0.0003517748,0.0003547988,0.0009780555],"category_scores_gemma":[0.0004681362,0.0001804635,0.0003960617,0.000440402,0.0002806923,0.0002129411,0.0003058171,0.0006608388,0.0006110604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003414508,"about_ca_system_score_gemma":0.000236961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001193095,"about_ca_topic_score_gemma":0.00285502,"domain_scores_codex":[0.9996954,0.00001717193,0.00001546648,0.0001422494,0.0001019817,0.00002770946],"domain_scores_gemma":[0.9995313,0.0001638086,0.0001108764,0.0000409958,0.0001142241,0.00003870142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009658498,0.00002378445,0.005376366,0.000182528,0.00007050953,0.00007687827,0.0001530345,0.001211799,0.9825833,0.0002751841,0.0004398772,0.009509985],"study_design_scores_gemma":[0.00003646505,0.0002198516,0.1785223,0.00005479254,0.0002244096,0.0005226638,0.0002797963,0.04564717,0.7596043,0.001135638,0.01366922,0.00008341911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9075114,0.001724975,0.07147785,0.000178603,0.00008416849,0.0001186497,0.01312551,0.001068963,0.004709827],"genre_scores_gemma":[0.900446,0.001226473,0.07576425,0.0005255727,0.00005934065,0.0003993489,0.0168987,0.0008259816,0.003854427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001193095,"threshold_uncertainty_score":0.003271937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03183780534138717,"score_gpt":0.269578085400525,"score_spread":0.2377402800591379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}