{"id":"W2126464915","doi":"10.1677/erc-09-0252","title":"Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase","year":2010,"lang":"en","type":"article","venue":"Endocrine Related Cancer","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":232,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Metformin; Fatty acid synthase; AMPK; Endocrinology; Internal medicine; PI3K/AKT/mTOR pathway; Protein kinase B; Apoptosis; Colorectal cancer; In vivo; Cancer research; Medicine; Insulin; Cancer; Phosphorylation; Biology; Protein kinase A; Lipid metabolism; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001617066,0.0002061874,0.0003746845,0.00007191966,0.0000429931,0.000005219941,0.0001299055,0.000142051,0.0001124889],"category_scores_gemma":[0.0001483834,0.0001277528,0.00006214184,0.0002079856,0.000150163,0.000006629685,0.00006112233,0.0002300892,1.41734e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002096092,"about_ca_system_score_gemma":0.00006914123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007965436,"about_ca_topic_score_gemma":0.0002561167,"domain_scores_codex":[0.9988847,0.0001417825,0.000253681,0.0003115598,0.0001745857,0.0002336676],"domain_scores_gemma":[0.9992536,0.00008786184,0.0002372301,0.0002592111,0.0001042241,0.00005789942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001794561,0.00008264263,0.006536345,0.00003721109,0.0001685024,0.000008052693,0.0001686158,0.00007849971,0.9862053,0.00010876,0.0003806855,0.004430831],"study_design_scores_gemma":[0.002816532,0.001171474,0.002731735,0.0001175016,0.00009469153,0.000003054871,0.00001542271,0.00007618425,0.992011,0.00005540138,0.0007595029,0.0001475503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984681,0.01458513,0.000005662419,0.00003192212,0.0001393692,0.0002344452,0.0001219781,0.00000612095,0.000194416],"genre_scores_gemma":[0.9965019,0.003053781,0.00001876819,0.00004688566,0.00004392112,0.0001146086,0.00002612973,0.00002403071,0.0001699983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01182092,"threshold_uncertainty_score":0.5209607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004109245404270566,"score_gpt":0.2338165142576911,"score_spread":0.2297072688534205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}