{"id":"W2126464915","doi":"10.1677/erc-09-0252","title":"Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase","year":2010,"lang":"en","type":"article","venue":"Endocrine Related Cancer","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":232,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Metformin; Fatty acid synthase; AMPK; Endocrinology; Internal medicine; PI3K/AKT/mTOR pathway; Protein kinase B; Apoptosis; Colorectal cancer; In vivo; Cancer research; Medicine; Insulin; Cancer; Phosphorylation; Biology; Protein kinase A; Lipid metabolism; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001906617,0.0005178548,0.0003547659,0.000410003,0.0001596602,0.0002328067,0.0002510347,0.0002932699,0.001195126],"category_scores_gemma":[0.0001771597,0.000227305,0.0003084336,0.0002237745,0.0002298326,0.0001881381,0.0001992633,0.0009236434,0.0002169386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003865578,"about_ca_system_score_gemma":0.0004874796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008948846,"about_ca_topic_score_gemma":0.002267851,"domain_scores_codex":[0.9998463,0.00003420948,0.0000167627,0.00001881441,0.00003914598,0.00004470915],"domain_scores_gemma":[0.9997607,0.000040082,0.00009324543,0.00002588678,0.00001692042,0.00006320498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001345992,0.0003837074,0.0003613422,0.00006719311,0.00001698548,0.00007413989,0.00001094255,0.0001343048,0.9944612,0.0001208057,0.00008750531,0.002935985],"study_design_scores_gemma":[0.0002674564,0.005636687,0.01393276,0.00001677616,0.00003548607,0.0003279552,0.00002749491,0.001691952,0.9752266,0.00008816514,0.002737457,0.00001107539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960705,0.001572235,0.0008792055,0.0001347105,0.00005499973,0.00004283171,0.0002553795,0.00006366058,0.0009265044],"genre_scores_gemma":[0.9927099,0.001885353,0.001950169,0.00009608798,0.00002907002,0.000101321,0.0007350151,0.00002462054,0.002468424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001195126,"threshold_uncertainty_score":0.003998101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004109245404270566,"score_gpt":0.2338165142576911,"score_spread":0.2297072688534205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}