{"id":"W2126503680","doi":"10.1128/mcb.24.16.7043-7058.2004","title":"RPAP1, a Novel Human RNA Polymerase II-Associated Protein Affinity Purified with Recombinant Wild-Type and Mutated Polymerase Subunits","year":2004,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Montreal Clinical Research Institute","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ontario Genomics; Ontario Genomics Institute; Genome Canada","keywords":"Biology; RNA polymerase II; Tandem affinity purification; Molecular biology; Transcription factor II D; Transcription (linguistics); Transcription factor II A; Protein subunit; Recombinant DNA; Polymerase; Saccharomyces cerevisiae; Transcription factor II F; Transcription preinitiation complex; Cell biology; DNA; Gene; Biochemistry; Affinity chromatography; Gene expression; Promoter; RNA-dependent RNA polymerase; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002157994,0.0008146515,0.0004100482,0.0003925938,0.00027161,0.0006067487,0.0006702017,0.0003919747,0.001961646],"category_scores_gemma":[0.0002541816,0.0003450382,0.0003870091,0.0003606071,0.0002237293,0.0003563326,0.000294157,0.0008380724,0.001980906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005010093,"about_ca_system_score_gemma":0.0002924337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005469697,"about_ca_topic_score_gemma":0.0006317029,"domain_scores_codex":[0.9998222,0.00001508187,0.00001436375,0.00006750517,0.00005843089,0.00002243349],"domain_scores_gemma":[0.9999012,0.00001889824,0.00001508134,0.00001038701,0.00002101709,0.00003337547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005626342,0.00002365741,0.0003193692,0.0001228796,0.00001435139,0.0001525627,0.00001509878,0.000112289,0.9937618,0.000216705,0.0004144389,0.004790495],"study_design_scores_gemma":[0.00003401762,0.000122741,0.003649,0.00002150449,0.00005048465,0.002330246,0.00001639619,0.002169712,0.9636568,0.0002441072,0.02768752,0.00001760101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8863953,0.03063747,0.06670153,0.001419992,0.0004375106,0.0003162026,0.005665125,0.001795914,0.006630893],"genre_scores_gemma":[0.8848771,0.009649191,0.06566093,0.0003526166,0.0001608567,0.0003212767,0.02253463,0.0003007292,0.01614263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001961646,"threshold_uncertainty_score":0.006562352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009281837066979657,"score_gpt":0.2158532891645401,"score_spread":0.2065714520975604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}