{"id":"W2126503680","doi":"10.1128/mcb.24.16.7043-7058.2004","title":"RPAP1, a Novel Human RNA Polymerase II-Associated Protein Affinity Purified with Recombinant Wild-Type and Mutated Polymerase Subunits","year":2004,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Montreal Clinical Research Institute","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ontario Genomics; Ontario Genomics Institute; Genome Canada","keywords":"Biology; RNA polymerase II; Tandem affinity purification; Molecular biology; Transcription factor II D; Transcription (linguistics); Transcription factor II A; Protein subunit; Recombinant DNA; Polymerase; Saccharomyces cerevisiae; Transcription factor II F; Transcription preinitiation complex; Cell biology; DNA; Gene; Biochemistry; Affinity chromatography; Gene expression; Promoter; RNA-dependent RNA polymerase; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002918328,0.0004240157,0.0003998622,0.0001049294,0.0004224341,0.00004379967,0.0002041155,0.0004783789,0.00001948318],"category_scores_gemma":[0.0001005573,0.0003654592,0.00007520576,0.0002514745,0.000278788,0.000008190813,0.0002001385,0.0002020695,0.00000292334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001932627,"about_ca_system_score_gemma":0.0001374767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004187538,"about_ca_topic_score_gemma":0.0000937882,"domain_scores_codex":[0.998024,0.000205294,0.0003234071,0.0007720708,0.0001254409,0.000549791],"domain_scores_gemma":[0.9990012,0.00000882053,0.0001834976,0.0004400036,0.00012774,0.0002387298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000281061,0.0002910518,0.0001232453,0.00001877223,0.0001824259,0.00008526061,0.00006947866,0.000003932152,0.9963161,0.001622481,0.000005624479,0.001000573],"study_design_scores_gemma":[0.002945294,0.002754617,0.0001012199,0.00005653563,0.00007696672,0.0000700083,0.00004985401,0.000003389786,0.9918541,0.0009451751,0.0006191296,0.0005237676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921189,0.003000806,0.003569551,0.0003353208,0.00008017661,0.0006212791,0.00002944405,0.00004412081,0.000200421],"genre_scores_gemma":[0.9978996,0.00007352328,0.0006936432,0.0003445925,0.0000399585,0.00006528644,0.0004734658,0.00006113879,0.00034878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005780731,"threshold_uncertainty_score":0.9998797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009281837066979657,"score_gpt":0.2158532891645401,"score_spread":0.2065714520975604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}