{"id":"W2126503833","doi":"10.1074/jbc.m111.223362","title":"Discovery of a Novel Site Regulating Glucokinase Activity following Characterization of a New Mutation Causing Hyperinsulinemic Hypoglycemia in Humans","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Glucokinase; Hyperinsulinemic hypoglycemia; Mutant; Internal medicine; Endocrinology; Maturity onset diabetes of the young; Wild type; Mutation; Hypoglycemia; Biology; Chemistry; Biochemistry; Type 2 diabetes; Insulin; Diabetes mellitus; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008779369,0.0002894381,0.0002326316,0.0001228023,0.0000715789,0.0002271306,0.0001589602,0.0002997809,0.0008436097],"category_scores_gemma":[0.000162444,0.00008671975,0.0002906107,0.0001281221,0.000128151,0.00006945617,0.00008359052,0.0003093976,0.0002760926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001327969,"about_ca_system_score_gemma":0.0001073917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000373685,"about_ca_topic_score_gemma":0.0002200761,"domain_scores_codex":[0.9999222,0.000008477648,0.00001036568,0.00003191167,0.00001734726,0.000009685842],"domain_scores_gemma":[0.9999291,0.00001292067,0.00002274343,0.000007251133,0.000006090793,0.00002185978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002736049,0.00003979582,0.002807036,0.00002749484,0.00001334306,0.0006904979,0.00002482202,0.0000866187,0.9916083,0.00009063245,0.00004518317,0.004292487],"study_design_scores_gemma":[0.0001093758,0.00140947,0.08619014,0.00002612756,0.0001270491,0.01455088,0.0001030627,0.002935966,0.8889799,0.0002534258,0.005287108,0.00002746115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959633,0.0003279113,0.002697735,0.00004236664,0.00002172646,0.00002005025,0.0003676082,0.00003688295,0.0005223622],"genre_scores_gemma":[0.9948991,0.0002777888,0.003309769,0.00006605843,0.00001140583,0.00001687542,0.0007498012,0.00002031773,0.0006488864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008436097,"threshold_uncertainty_score":0.002822161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05238990800170416,"score_gpt":0.2709413174288727,"score_spread":0.2185514094271686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}