{"id":"W2126518605","doi":"10.1111/j.1600-0447.2009.01529.x","title":"An update on the role of glutamate in the pathophysiology of depression","year":2010,"lang":"en","type":"review","venue":"Acta Psychiatrica Scandinavica","topic":"Treatment of Major Depression","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Alberta Hospital; Alberta Hospital Edmonton","funders":"Canadian Institutes of Health Research; Health Canada; Canada Research Chairs","keywords":"Glutamatergic; Neurochemical; Animal models of depression; Glutamate receptor; Antidepressant; Pathophysiology; Neuroscience; Depression (economics); Major depressive disorder; Medicine; Psychology; Psychiatry; Receptor; Internal medicine; Cognition; Hippocampus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007916435,0.001244855,0.002035325,0.003786396,0.0003042311,0.001268554,0.001137684,0.00146916,0.004383121],"category_scores_gemma":[0.001111186,0.0003581122,0.0008831851,0.004482614,0.0003883746,0.001652103,0.0006371861,0.001680843,0.001677948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008219034,"about_ca_system_score_gemma":0.001711579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001782156,"about_ca_topic_score_gemma":0.003888863,"domain_scores_codex":[0.9997074,0.00006232973,0.00008096524,0.00003776,0.00008660032,0.00002493468],"domain_scores_gemma":[0.9993778,0.0003020742,0.0001133486,0.00001360186,0.0001505133,0.00004271496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001795449,0.00008832771,0.0003648708,0.06855393,0.0003985622,0.0009096729,0.0001975062,0.000340329,0.001658387,0.002259223,0.08381371,0.8412359],"study_design_scores_gemma":[0.00004158477,0.000137701,0.001949356,0.02147718,0.0007570763,0.003584144,0.0001603261,0.00009373704,0.0002082803,0.001432549,0.97013,0.0000280596],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009457888,0.9986131,0.00004913158,0.0003517387,0.00043822,0.000003143757,0.00001796339,0.000004442995,0.0004276533],"genre_scores_gemma":[0.0004711958,0.9983341,0.0001731127,0.0003305493,0.0003831002,0.000004203195,0.00003027845,9.242232e-7,0.0002725559],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004383121,"threshold_uncertainty_score":0.01466298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01641002334054196,"score_gpt":0.3303388248730426,"score_spread":0.3139288015325006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}