{"id":"W2126548430","doi":"10.1074/jbc.m506812200","title":"Promoter Organization of the Interferon-A Genes Differentially Affects Virus-induced Expression and Responsiveness to TBK1 and IKK∈","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research; Centre National de la Recherche Scientifique; Association pour la Recherche sur le Cancer","keywords":"TANK-binding kinase 1; Promoter; IκB kinase; IRF1; Transcription factor; Interferon regulatory factors; Biology; Interferon; Transcription (linguistics); Molecular biology; Response element; CREB; Gene; Kinase; Gene expression; Cell biology; Genetics; Protein kinase A; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001845422,0.0001197964,0.0002495758,0.0000295245,0.00007003656,0.00001266964,0.0001831079,0.000227743,0.0002056379],"category_scores_gemma":[0.0003546152,0.00006304029,0.00005197237,0.0000553268,0.0001234274,0.00004385567,0.0002038834,0.0002169316,0.000002988025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002195653,"about_ca_system_score_gemma":0.00003349684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001029223,"about_ca_topic_score_gemma":5.099016e-7,"domain_scores_codex":[0.9992484,0.0001941948,0.0002749378,0.0001244399,0.00003269981,0.0001252646],"domain_scores_gemma":[0.9993961,0.000127108,0.0002187074,0.0001151296,0.0001143911,0.00002859627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009803643,0.00007375569,0.001938892,0.00001952014,0.0000345341,0.000001352691,0.0001571097,4.590864e-7,0.9930342,0.000002781008,0.0001188397,0.003638229],"study_design_scores_gemma":[0.0005239029,0.0003971882,0.02790007,0.0001481736,0.00001530337,0.0002349042,0.00009695677,3.819213e-7,0.9693376,0.000006682261,0.001263139,0.00007564497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981983,0.001033685,0.00006835472,0.0004489391,0.0001267702,0.0000800882,0.000004826804,0.000005886671,0.00003317703],"genre_scores_gemma":[0.9994006,0.0001413087,0.00005467857,0.00008677203,0.00004927354,0.000001128221,0.000002339777,0.000006258184,0.0002576795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02596118,"threshold_uncertainty_score":0.2570708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0142250537613738,"score_gpt":0.2420630517943341,"score_spread":0.2278379980329603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}