{"id":"W2126548430","doi":"10.1074/jbc.m506812200","title":"Promoter Organization of the Interferon-A Genes Differentially Affects Virus-induced Expression and Responsiveness to TBK1 and IKK∈","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research; Centre National de la Recherche Scientifique; Association pour la Recherche sur le Cancer","keywords":"TANK-binding kinase 1; Promoter; IκB kinase; IRF1; Transcription factor; Interferon regulatory factors; Biology; Interferon; Transcription (linguistics); Molecular biology; Response element; CREB; Gene; Kinase; Gene expression; Cell biology; Genetics; Protein kinase A; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001340647,0.0002201691,0.000215202,0.0001617565,0.0001208909,0.000240279,0.0002011453,0.0001761165,0.0009585579],"category_scores_gemma":[0.0001775437,0.0001959092,0.0002999736,0.00007236868,0.0002405729,0.0001276862,0.0002173976,0.00048516,0.0004817553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003478719,"about_ca_system_score_gemma":0.0002917837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005663316,"about_ca_topic_score_gemma":0.0006009378,"domain_scores_codex":[0.9997715,0.00003538909,0.00002141876,0.00006449236,0.00004230848,0.00006486988],"domain_scores_gemma":[0.9998026,0.00003150119,0.00006279953,0.00002547116,0.0000225184,0.00005504546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008669218,0.000009607473,0.0001962557,0.000008846363,0.000001521469,0.00001187044,0.000007934867,0.00001932643,0.9993381,0.00003749247,0.000003939024,0.0002783082],"study_design_scores_gemma":[0.00001775223,0.000126665,0.007239753,0.000008934966,0.00001304008,0.0002159616,0.00003249813,0.00101624,0.9903799,0.00005791225,0.0008849335,0.000006526584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974082,0.0004731574,0.001545393,0.00002068319,0.00001760654,0.00000918268,0.0001152586,0.00003472815,0.0003756759],"genre_scores_gemma":[0.9970266,0.0001704762,0.001571763,0.00001721468,0.000003959055,0.00002040675,0.0003839014,0.00002591293,0.0007797813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009585579,"threshold_uncertainty_score":0.00320673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0142250537613738,"score_gpt":0.2420630517943341,"score_spread":0.2278379980329603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}