{"id":"W2126560192","doi":"10.1073/pnas.0437998100","title":"Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase IIIβ","year":2003,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Biology; Topoisomerase; Meiosis; Genetics; DNA; Aneuploidy; Chromosome segregation; RAD51; Molecular biology; Homologous recombination; Chromosome; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005572202,0.00004845158,0.0000641505,0.00004060003,0.00004919666,0.000008181701,0.0001616248,0.00005299763,0.00000351038],"category_scores_gemma":[0.0001767582,0.00003595773,0.00002025594,0.0002189723,0.0001888242,0.00001067774,0.00004980696,0.00005239041,1.042484e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007879023,"about_ca_system_score_gemma":0.00002863794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005268979,"about_ca_topic_score_gemma":6.681012e-7,"domain_scores_codex":[0.9994338,0.00000463649,0.0001275085,0.000148556,0.0002036798,0.00008185869],"domain_scores_gemma":[0.9997798,0.0000103927,0.00009564018,0.000005371187,0.00009183792,0.00001698165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001395926,0.00001776021,0.006628645,0.00001630573,0.000004025339,2.194311e-9,0.00004701503,0.00000797852,0.9798998,0.01320767,0.00002008918,0.0001367227],"study_design_scores_gemma":[0.0001643202,0.0000580824,0.02375411,0.00001627655,0.000003095627,0.00000511239,0.00007254102,0.00005130864,0.9564806,0.01852224,0.0008224483,0.00004992176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976355,0.0005498014,6.613216e-7,0.0003399469,0.00001387154,0.00007137006,0.000002850341,0.000001187273,0.001384793],"genre_scores_gemma":[0.9991852,0.0001150739,0.000314546,0.0003102419,0.00001697792,0.000002634301,9.606573e-8,0.000001975098,0.00005322088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02341928,"threshold_uncertainty_score":0.1466314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03357783607487222,"score_gpt":0.3165871413740659,"score_spread":0.2830093052991937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}