{"id":"W2126560192","doi":"10.1073/pnas.0437998100","title":"Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase IIIβ","year":2003,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Biology; Topoisomerase; Meiosis; Genetics; DNA; Aneuploidy; Chromosome segregation; RAD51; Molecular biology; Homologous recombination; Chromosome; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001370613,0.0004841242,0.0002187614,0.0008042813,0.0001534656,0.0002454324,0.0001831787,0.0003547102,0.001431608],"category_scores_gemma":[0.0001535981,0.0003034406,0.0002863,0.0002081568,0.0003123274,0.000188645,0.00025338,0.0007366472,0.0002730359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001206929,"about_ca_system_score_gemma":0.00009324813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003043225,"about_ca_topic_score_gemma":0.0003776896,"domain_scores_codex":[0.9998877,0.0000144728,0.00001127777,0.00003943313,0.00003061005,0.00001641447],"domain_scores_gemma":[0.9997619,0.00002285008,0.0001246582,0.00002180815,0.00001337943,0.0000554745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001633081,0.00002209001,0.002142762,0.00002372318,0.00001771551,0.0003405168,0.00002945428,0.0000438369,0.9949369,0.0001458693,0.00005357381,0.002080296],"study_design_scores_gemma":[0.0001371164,0.001685324,0.1409671,0.00005090661,0.0002042595,0.01079524,0.0001488534,0.000974886,0.8373113,0.0007351461,0.006962304,0.00002765497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917788,0.002109695,0.00382239,0.0001329188,0.00003746467,0.00001792106,0.0004602721,0.0002012406,0.001439275],"genre_scores_gemma":[0.9897807,0.002056326,0.001832595,0.0001371412,0.00002937679,0.00004349677,0.0007249916,0.00007788898,0.005317551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001431608,"threshold_uncertainty_score":0.004789233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03357783607487222,"score_gpt":0.3165871413740659,"score_spread":0.2830093052991937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}