{"id":"W2126563569","doi":"10.1128/iai.71.11.6499-6509.2003","title":"Recombinant<i>Leishmania major</i>Secreting Biologically Active Granulocyte-Macrophage Colony-Stimulating Factor Survives Poorly in Macrophages In Vitro and Delays Disease Development in Mice","year":2003,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Medical Research Council; Canadian Institutes of Health Research","keywords":"Biology; In vitro; Macrophage; Recombinant DNA; Granulocyte macrophage colony-stimulating factor; Leishmania; Colony-stimulating factor; Immunology; Leishmania major; Granulocyte; Microbiology; Leishmaniasis; Biological activity; Cytokine; Cell biology; Biochemistry; Haematopoiesis; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001581998,0.0002537741,0.000146769,0.0001727411,0.00006323282,0.0002384776,0.0001338243,0.0002143602,0.000763552],"category_scores_gemma":[0.0001268592,0.00008721992,0.0001177768,0.0000742122,0.0002191903,0.0001381641,0.00009426366,0.0004633059,0.0004757463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001725018,"about_ca_system_score_gemma":0.0001289234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002469175,"about_ca_topic_score_gemma":0.0003329336,"domain_scores_codex":[0.9999197,0.00002195166,0.000006461696,0.0000137654,0.00001878786,0.00001937307],"domain_scores_gemma":[0.9998786,0.00002114014,0.00003775904,0.00001727868,0.0000156981,0.00002940319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001060993,0.00002798449,0.000125266,0.00002470207,0.000002238164,0.0000208738,0.000006631601,0.00001460947,0.9981819,0.00009298434,0.00005891373,0.001337644],"study_design_scores_gemma":[0.00003572667,0.000582642,0.00195741,0.000009950065,0.00001581413,0.0003841563,0.00001185345,0.0001755924,0.9913417,0.00007943243,0.005403397,0.000002326627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883416,0.003868659,0.00369767,0.0003896015,0.00004105766,0.00003061855,0.0003138766,0.0001706621,0.003146227],"genre_scores_gemma":[0.9878825,0.002027049,0.005302215,0.0001482605,0.00002901786,0.00002766332,0.001128678,0.00004729535,0.003407352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000763552,"threshold_uncertainty_score":0.002554357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02598249300604146,"score_gpt":0.2941376889790943,"score_spread":0.2681551959730529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}