{"id":"W2126586049","doi":"10.1093/hmg/ddn043","title":"Mice deficient in Neu4 sialidase exhibit abnormal ganglioside catabolism and lysosomal storage","year":2008,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Calgary; McGill University; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale; McGill University","keywords":"Biology; Sialidase; Catabolism; Ganglioside; Cell biology; Lysosomal storage disease; Endocrinology; Biochemistry; Metabolism; Internal medicine; Enzyme; Neuraminidase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002324332,0.002175632,0.0005157308,0.001512306,0.0003476665,0.0005720063,0.0004137716,0.001346251,0.004382],"category_scores_gemma":[0.0002802438,0.0006268806,0.0005487663,0.0005230039,0.000831825,0.0004066559,0.0005376035,0.0009241777,0.001414318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004595345,"about_ca_system_score_gemma":0.0003385195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009191806,"about_ca_topic_score_gemma":0.001427142,"domain_scores_codex":[0.9996753,0.00003532748,0.00004589705,0.00009571635,0.00007363623,0.00007413221],"domain_scores_gemma":[0.9993332,0.00007964247,0.0003317725,0.00005160133,0.00003663461,0.0001671042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002291896,0.00004113797,0.0005898685,0.00004351923,0.00002585575,0.0006387669,0.00004045023,0.0001678092,0.9965559,0.000277856,0.0001005833,0.00128911],"study_design_scores_gemma":[0.0002438766,0.001021048,0.03054133,0.00008186084,0.0002316588,0.01118897,0.0001981568,0.002844993,0.9460791,0.0009995262,0.006499785,0.00006971732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885386,0.001187281,0.004558974,0.0001897497,0.0000430212,0.00004770359,0.002526126,0.0008336192,0.002074992],"genre_scores_gemma":[0.9705514,0.001877459,0.008620457,0.0001805767,0.00004034162,0.0001293915,0.002921628,0.0004062217,0.01527245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004382,"threshold_uncertainty_score":0.01465929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01554347797482053,"score_gpt":0.263683370494564,"score_spread":0.2481398925197435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}